◀ Back to MAP2K1

ESR1 — MAP2K1

Text-mined interactions from Literome

Kronblad et al., Oncogene 2005 (Breast Neoplasms) : Hypoxia further caused transcriptional downregulation of ERalpha via activation of ERK1/2 in cell lines and, importantly, MEK1/2 inhibitors ( U0126 or PD184352 ) or ERK1/2 suppression by siRNA partially restored the ERalpha expression
Britton et al., Breast Cancer Res Treat 2006 (Breast Neoplasms) : Phosphorylation of ERalpha at S118 was regulated by the EGFR/MAPK pathway in Tam-R cells being increased in response to amphiregulin (AR) and inhibited by the selective EGFR tyrosine kinase inhibitor, gefitinib and the MEK1/2 inhibitor, PD184352