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CYP1A2 — IL6

Text-mined interactions from Literome

Dickmann et al., Drug Metab Dispos 2011 : IL-6 suppressed induction of CYP1A2 enzyme activity by omeprazole and CYP3A4 enzyme activity by rifampicin but only at supraphysiological concentrations of IL-6 ... A monoclonal antibody directed against IL-6 abolished or partially blocked IL-6 mediated suppression of CYP1A2 and CYP3A4 enzyme activity, respectively
Barker et al., J Biol Chem 1994 : We have previously shown that the inflammatory mediator interleukin-1 suppressed transcription of CYP1A1 and CYP1A2 mRNAs ( Barker, C.W., Fagan, J.B., and Pasco, D.S. ( 1992 ) J. Biol. Chem. 267, 8050-8055 )
Calleja et al., Biochem Biophys Res Commun 1997 : Differential effects of interleukin-1 beta, interleukin-2 , and interferon-gamma on the inducible expression of CYP 1A1 and CYP 1A2 in cultured rabbit hepatocytes