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NOX4 — PRKAA1
Text-mined interactions from Literome
Sharma et al., J Clin Invest 2008
(Albuminuria...) :
These effects seemed to be caused by reduction of oxidative stress, as adiponectin and
AMPK activation both
reduced protein levels of the NADPH oxidase
Nox4 in podocytes
McCarty et al., Med Hypotheses 2009
:
These phenomena become predictable if we postulate that
AMPK can
inhibit activation of
NADPH oxidase ... Such an effect would make sense from a homeostatic perspective, and moreover there is direct evidence that
AMPK suppresses
NADPH oxidase activation in neutrophils
Wang et al., Circ Res 2010
:
Analysis of aortic endothelial cells from AMPKalpha2 ( -/- ) mice and human umbilical vein endothelial cells expressing dominant negative AMPK or AMPKalpha2-specific siRNA revealed that loss of
AMPK activity
increased NAD ( P ) H oxidase subunit expression ( gp91(phox), p47(phox), p67(phox), NOX1 and -4 ),
NAD ( P ) H oxidase mediated superoxide production, 26S proteasome activity, IkappaBalpha degradation, and nuclear translocation of NF-kappaB ( p50 and p65 ), whereas AMPK activation by AICAR or overexpression of constitutively active AMPK had the opposite effect
Eid et al., J Biol Chem 2010
(Diabetes Mellitus...) :
Activation of
AMPK blocked HG-induced expression of Nox4,
NADPH oxidase activity, and apoptosis ... Activation of
AMPK blocked HG-induced expression of
Nox4 , NADPH oxidase activity, and apoptosis ... Pharmacologic activation of
AMPK by 5-aminoimidazole-4-carboxamide-1-riboside in OVE26 mice
attenuated Nox4 and p53 expression
Tang et al., Free Radic Biol Med 2011
(Pneumonia) :
Inhibition of
NADPH oxidase activation by apocynin or siRNA targeting p47(phox) ( a subunit of NADPH oxidase )
attenuated the increased intracellular ROS level,
AMPK activation, and IL-8 induction
Fitzgerald et al., PloS one 2012
(Carcinoma, Renal Cell...) :
Finally, we have characterized that enhanced levels of IL-6 and IL-8 result in RCC cell invasion and that activation of
AMPK reduces
Nox4 expression, IL-6 and IL-8 production, and RCC cell invasion