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CDC73 — MMP2

Text-mined interactions from Literome

Axelrad et al., FASEB J 2004 (Adenocarcinoma...) : Platelet activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration
Ottino et al., Invest Ophthalmol Vis Sci 2005 : PAF , through a receptor mediated mechanism, induces a specific pattern of furin, MMP , and TIMP-2 expression in corneal myofibroblasts
Melnikova et al., J Biol Chem 2006 (Melanoma...) : Furthermore, PAF stimulated the gelatinase activity of MMP-2 by activating transcription and MMP-2 expression ... PAF induced expression of pro-MMP-2 was causally related to PAF induced CREB and ATF-1 phosphorylation ; it was prevented by PAFR antagonist and inhibitors of p38 MAPK and protein kinase A and was abrogated upon quenching of CREB and ATF-1 activities by forced overexpression of a dominant negative form of CREB ... PAF induced MMP-2 activation was also down-regulated by p38 MAPK and protein kinase A inhibitors
Zhou et al., Am J Physiol Heart Circ Physiol 2007 : Increased alkaline phosphatase ( AP ) activity after PAF treatment in AP-HB-EGF fusion construct transfected SMCs indicated that PAF induced the release of HB-EGF within 1 min. Gelatin zymography data showed that PAF stimulated MMP-2 activity and MMP-9 activity within 1 min
Melnikova et al., Cancer Metastasis Rev 2007 (Inflammation...) : Furthermore, we showed that PAF stimulated the phosphorylation of CREB and ATF-1 in metastatic melanoma cells, which resulted in overexpression of MMP-2 and MT1-MMP