Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
THBS1
→
KRAS
(decreases)
Evidence: When the Bcl-2 oncogene which mediates inhibition of apoptosis [52], was transfected into tumor cells, tumor cell apoptosis decreased and VEGF expression increased significantly [48]. In another study, human osteosarcoma cells implanted in mice formed only microscopic avascular, dormant tumors, in which tumor cell proliferation was balanced by tumor cell apoptosis. When these cells were transfected with the ras oncogene, VEGF expression doubled, expression of thrombospondin decreased significant...