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ABL1 — RAD51

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RAD51 → ABL1 (directlyIncreases, RAD51 Activity)
  Evidence: 11684015;10212258
• WikiPathways miRNA Regulation of DNA Damage Response: ABL1 → RAD51 (activation) Sengupta et al., Nat Rev Mol Cell Biol 2005*, Harrison et al., Annu Rev Genet 2006*, Toledo et al., Nat Rev Cancer 2006*, Vousden et al., Nat Rev Mol Cell Biol 2007*, Boutros et al., Nat Rev Cancer 2007*, Wang et al., Nat Rev Genet 2007*, Löbrich et al., Nat Rev Cancer 2007*, Antoni et al., Nat Rev Cancer 2007*
• WikiPathways ATM Signaling Pathway: ABL1 → RAD51 (mim-stimulation)
• WikiPathways DNA Damage Response: ABL1 → RAD51 (activation) Sengupta et al., Nat Rev Mol Cell Biol 2005*, Harrison et al., Annu Rev Genet 2006*, Toledo et al., Nat Rev Cancer 2006*, Vousden et al., Nat Rev Mol Cell Biol 2007*, Boutros et al., Nat Rev Cancer 2007*, Wang et al., Nat Rev Genet 2007*, Löbrich et al., Nat Rev Cancer 2007*, Antoni et al., Nat Rev Cancer 2007*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RAD51 — ABL1 (physical association, affinity chromatography technology) Chen et al., J Biol Chem 1999*
• IRef Biogrid Interaction: RAD51 — ABL1 (direct interaction, pull down) Chen et al., J Biol Chem 1999*
• IRef Hprd Interaction: RAD51 — ABL1 (in vitro) Chen et al., J Biol Chem 1999*, Yuan et al., J Biol Chem 1998*
• IRef Hprd Interaction: RAD51 — ABL1 (in vivo) Chen et al., J Biol Chem 1999*, Yuan et al., J Biol Chem 1998*
• IRef Intact Interaction: RAD51 — ABL1 (physical association, pull down) Popova et al., FEBS Lett 2009*

Text-mined interactions from Literome

Chen et al., J Biol Chem 1999 : Our data suggest signaling mediated through ATM, and c-Abl is required for the correct post-translational modification of Rad51 , which is critical for the assembly of Rad51 repair protein complex following I-R
Slupianek et al., Mol Cell 2001 : BCR/ABL significantly enhances the expression of RAD51 and several RAD51-Paralogs
Yuan et al., Mutat Res 2003 (Chromosome Breakage) : In conclusion, effective and prompt IR-induced Rad51 focus formation is cell cycle regulated and requires both ATM and c-Abl
Slupianek et al., Blood 2011 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : In conclusion, we postulate that BCR-ABL1 kinase mediated RAD51 ( pY315 ) promotes unfaithful HomeoRR in leukemia cells, which may contribute to accumulation of secondary chromosomal aberrations responsible for CML relapse and progression
Yuan et al., J Biol Chem 1998 : The results also show that treatment of cells with ionizing radiation induces c-Abl dependent phosphorylation of Rad51