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LCN2 — VEGFA

Text-mined interactions from Literome

Venkatesha et al., Mol Cancer Res 2006 (Neovascularization, Pathologic) : Here, we show that lipocalin 2 can suppress the ras induced expression of vascular endothelial growth factor in 4T1 cells via down-regulation of ras mitogen activated protein kinase and ras phosphatidylinositol-3-kinase signaling
Yang et al., FASEB J 2013 (Breast Neoplasms...) : Treatment with a VEGF neutralizing antibody demonstrates that VEGF is essential for the angiogenic activity of Lcn2 ... We further demonstrate that Lcn2 induced VEGF is mediated through hypoxia-inducible factor 1a (HIF-1a) and that Lcn2 regulates HIF-1a through extracellular signal regulated kinase ( Erk ) ... The regulation of HIF-1a and VEGF by Lcn2 was also demonstrated in the aggressive MDA-MB-231 cell line