Gene interactions and pathways from curated databases and text-mining

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MAP2K4 — MIP

Text-mined interactions from Literome

Watson et al., Mol Pharmacol 2005 (MAP Kinase Signaling System) : MIP-2 activated extracellular signal regulated kinase ( ERK ) 1/2 and Akt and both the mitogen activated protein kinase kinase 1 ( MEK1 ) and phosphatidylinositol 3-kinase (PI3K) inhibitors 2'-amino-3'-methoxyflavone ( PD98059 ) and wortmannin reduced the neuroprotective effect of MIP-2
Cheng et al., Mol Cell Biol 2005 : In particular, Mip1 prevented MEKK2 activation by blocking MEKK2 dimer formation, which in turn blocked JNKK2 , c-Jun N-terminal kinase 1 ( JNK1 ), extracellular signal regulated kinase 5, and AP-1 reporter gene activation by MEKK2