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Wadsworth et al., Biochem Pharmacol 1999 : Unexpectedly, the wine polyphenolics quercetin and resveratrol and the antioxidant N-acetylcysteine (NAC) did not inhibit LPS induced activation of the NF-KB complex p50/65 , as determined by mobility shift
Fine et al., J Neuroimmunol 1999 (AIDS Dementia Complex) : In addition, we performed electrophoretic mobility shift analysis and determined that in microglia, the p50/p65 heterodimer of NF-kappaB is activated by LPS stimulation, and is inhibited by MG132
Adams et al., J Cell Biochem 2000 : This rel/bZIP heteromer complex activated by PGG-Glucan is different from the p65/p50 rel/rel complex induced in these cells by lipopolysaccharide (LPS)
Jeon et al., J Pharmacol Exp Ther 2000 (MAP Kinase Signaling System) : LPS induced loss of inhibitory proteins IkappaB-alpha and IkappaB-beta and translocation of p65 , c-Rel, and p50 was inhibited by radicicol
Fessele et al., FASEB J 2001 : R ( A ) constitutively binds Sp1, and Rel p50/p65 following LPS stimulation
Petro et al., Int Immunopharmacol 2003 : STE also stimulated IFN-gamma induced activation of NF-kappaB p50 but reduced nuclear localization of IFN-gamma- and IFN-gamma/LPS induced NF-kappaB p65
Yang et al., J Immunol 2003 : Using mouse embryonic fibroblasts lacking either IKK alpha or IKK beta, we found that IKK beta played an essential role in LPS induced p65 phosphorylation on serine 536, while IKK alpha was partially required for the p65 phosphorylation ... The LPS induced p65 phosphorylation on serine 536 was independent of the phosphatidylinositol 3'-kinase/Akt signaling pathway
Németh et al., J Pharmacol Exp Ther 2003 : Furthermore, adenosine as well as adenosine receptor agonists failed to decrease LPS induced NF-kappaB DNA binding, NF-kappaB promoter activity, p65 nuclear translocation, and inhibitory kappaB degradation
Martin et al., J Immunol 2003 (MAP Kinase Signaling System) : Inhibition of P. gingivalis LPS mediated activation of the PI3K-Akt pathway resulted in a pronounced augmentation of NF-kappaB p65 that was independent of IkappaB-alpha degradation
Kim et al., Biochem Pharmacol 2003 : However, luteolin prevented LPS stimulated interaction between the p65 subunit of NF-kappa B and the transcriptional coactivator CBP
Barhoumi et al., Brain Res Mol Brain Res 2004 (Manganese Poisoning) : LPS induced DNA binding of p65/p50 was similarly enhanced by Mn and was decreased by mutant IkappaBalpha
Goriely et al., J Exp Med 2004 : We found that LPS induced p65 activation was similar in adult and newborn DCs
Currie et al., J Pediatr 2004 (Bacteremia...) : Lipopolysaccharide (LPS) induced translocation of NF-kappaB p50 and p65 and the kinetics of LPS induced cytokine mRNA transcription were normal except for IL-6 and IL-12p40, which were poorly transcribed
Yip et al., J Bone Miner Res 2004 (Bone Resorption...) : Furthermore, PAR inhibited LPS induced NF-kappaB activation, p65 translocation, and IkappaB-alpha degradation both in mature osteoclasts and their precursors in a time- and dose dependent manner
Kim et al., Biochem Biophys Res Commun 2004 : Furthermore, the compound inhibited LPS induced nuclear translocation of NF-kappaB p65 and DNA binding activity of NF-kappaB complex, in parallel, but did not affect IkappaBalpha degradation
Kim et al., Biochem Pharmacol 2005 : Furthermore, the compound inhibited LPS mediated nuclear translocation of NF-kappaB p65 and DNA binding activity of NF-kappaB complex, in parallel, but did not influence LPS mediated IkappaBalpha degradation
Jiang et al., Di Yi Jun Yi Da Xue Xue Bao 2005 : Mouse serum containing Liangge San can inhibit LPS induced p65 expression in mouse macrophages in a dose dependent manner, which may be one of the signal transduction mechanisms of the detoxifying effect of Liangge San
Chang et al., J Dent Res 2005 : However, unlike in monocytes, we found that LPS could not induce the phosphorylation of the NF-kappaB active subunit p65 in DPSCs
Hagi et al., Microbiol Immunol 2006 : These findings suggest that an as yet unknown H-89-sensitive serine kinase is rapidly activated by LPS stimulation and then phosphorylates p65/L-plastin , playing a vital role in macrophage activation
Yang et al., Mol Immunol 2007 : Moreover, LPS activated NFkappaB p65 , ERK1/2 and JNK1/2 and induced their translocation to the nucleus
Lee et al., J Cell Physiol 2007 (Dermatitis, Contact...) : Silibinin also inhibited the LPS induced activation of MAPKs and the nuclear translocation of the NF-kappaB p65 subunit
Liu et al., Life Sci 2007 : Other flavonoids, quercetin and cyanidin, which lack alpha, beta unsaturated carbonyl group, showed weaker or no inhibitory effect on both IL-6 induced STAT3 phosphorylation and LPS induced p65 translocation
Ganguly et al., Immunol Cell Biol 2008 (Tuberculosis) : These proteins also downregulated the bacterial lipopolysaccharide (LPS) induced ROS production, which, in turn, downregulated LPS induced nuclear factor-kappaB (NF-kappaB) p65 DNA binding activity, as well as inhibited the NF-kappaB dependent reporter gene ( chloramphenicol acetyl transferase ) expression in the treated macrophages
Cho et al., J Nutr 2008 (Inflammation) : In addition, DIM suppressed LPS induced nuclear factor-kappaB (NF-kappaB) transcriptional activity, NF-kappaB DNA binding activity, translocation of p65 ( RelA ) to the nucleus, and degradation of inhibitor of kappaB alpha
Zheng et al., Eur J Pharmacol 2008 (Neurotoxicity Syndromes) : In addition, the catechols inhibited LPS induced nuclear translocation of p65 subunit of nuclear factor (NF)-kappaB, IkappaB degradation, and phosphorylation of p38 mitogen activated protein kinase ( MAPK ) in BV-2 cells
de Seigneux et al., J Biol Chem 2008 : Chromatin immunoprecipitation showed that LPS increased p65 binding to two NF-kappaB sites along the SGK1 promoter
Roach et al., Shock 2009 : Furthermore, immunofluorescent microscopy revealed HBOC induced HO-1 inhibited LPS stimulated nuclear translocation of the p65 subunit of nuclear factor-kappaB
Turnbull et al., Journal of inflammation (London, England) 2008 : LPS stimulated loss of cytoplasmic IkappaBalpha and nuclear translocation of the p65 NF-kappaB subunit was inhibited by the active NO-furoxans
Oh et al., Eur J Pharmacol 2008 (Inflammation) : LPS induced p65 phosphorylation, which is mediated by extracellular signal regulated kinase ( ERK ) and Akt pathways, was attenuated by withaferin A treatment
Zhang et al., Zhongguo Dang Dai Er Ke Za Zhi 2008 (Bronchopulmonary Dysplasia...) : LPS or hyperoxia stimulation induced the nuclear translocation of p50 and p65 at 30 minutes of exposure ... A stimulation of LPS combined with hyperoxia induced the nuclear translocation of p50 and p65
Jeong et al., Int Immunopharmacol 2009 : Moreover, CTXA inhibited the induced phosphorylation and degradation of IkappaB-alpha as well as the LPS induced increase in p65 in the nuclear fraction of macrophages
Walton et al., Am J Physiol Gastrointest Liver Physiol 2009 : LPS induced rapid phosphorylation of NF-kappaB p65 , Akt, and p38 MAPK and degradation of Ikappa-Balpha
Jin et al., Bioorg Med Chem Lett 2009 : They inhibited NO production through the suppression of the LPS induced translocation of p65 subunit of NF-kappaB and the followed suppression of the iNOS protein and mRNA expression
Cerciat et al., Glia 2010 : Finally, we report that news SERMs, ospemifene and bazedoxifene, exert anti-inflammatory actions by a mechanism involving classical estrogen receptors and by the inhibition of LPS induced NFkappaB p65 transactivation
Oh et al., Chem Biol Interact 2009 (Ear Diseases...) : In addition, 4-O-methylhonokiol inhibited the LPS induced transcriptional and DNA binding activities of NF-kappaB as well as p50 and p65 translocation into the nucleus
Shi et al., Clin Exp Pharmacol Physiol 2010 (Atherosclerosis...) : In contrast, LPS activated p50 and p65 only in HAEC
Ban et al., Arthritis Res Ther 2009 (Arthritis, Experimental...) : Moreover, thiacremonone inhibited LPS induced p50 and p65 nuclear translocation, resulting in an inhibition of the DNA binding activity of the NF-kappaB
Lee et al., Biochem Biophys Res Commun 2010 : alpha-iso-cubebenol also inhibited LPS induced nuclear translocation of the NF-kappaB p65 subunit
Kalluri et al., FEBS J 2010 (Inflammation) : RSCL-0409 significantly inhibited p65 nuclear translocation induced by LPS
Wang et al., FASEB J 2010 (Hypercapnia) : Notably, hypercapnia did not affect LPS induced degradation of IkappaB alpha, nuclear translocation of RelA/p65 , or activation of mitogen activated protein kinases, but it did block IL-6 promoter-driven luciferase activity in mouse RAW 264.7 macrophages
Kim et al., Journal of clinical biochemistry and nutrition 2010 : Both THAA and AA prevented the LPS induced nuclear translocation of the nuclear factor-kappaB/p65 subunit, suggesting that THAA may inhibit the production of pro-inflammatory mediators through the same mechanism as AA
Choo et al., Rheumatology (Oxford) 2010 (Arthritis, Rheumatoid) : In addition, MS-275 and SAHA suppressed lipopolysaccharide (LPS) induced NF-kappaB p65 nuclear accumulation, IL-6, IL-18 and nitric oxide ( NO ) secretion as well as down-regulated pro-angiogenic VEGF and MMP-2 and MMP-9 production in E11 cells at sub-micromolar levels ... At similar concentrations, MS-275 and SAHA suppressed LPS induced NF-kappaB p65 nuclear accumulation and IL-1beta, IL-6, IL-18 and TNF-alpha secretion in THP-1 monocytic cells
Wiesner et al., Circ Res 2010 (Atherosclerosis...) : In a nuclear factor-DNA binding assay, the cooperative effect of mmLDL and LPS costimulation on c-Jun and c-Fos DNA binding, but not on p65 or p50, was dependent on mmLDL induced activation of extracellular signal regulated kinase ( ERK ) 1/2
Hseu et al., Food Chem Toxicol 2010 : Immunohistochemical staining revealed that A. camphorata suppressed production of the LPS induced tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and NF-kappaB p65 subunit in these organs
Qin et al., Sheng Li Xue Bao 2010 (Atherosclerosis...) : The expressions of NFkappaB p65 were attenuated in macrophages from SMS2 ( -/- ) mice in response to LPS stimulation compared with those of the WT mice
Bielecka et al., Naunyn Schmiedebergs Arch Pharmacol 2010 : Moreover, moclobemide decreased LPS stimulated translocation of NF?B p65 subunit into cellular nuclei
Patial et al., J Cell Physiol 2011 (Inflammation) : LPS induced I?Ba phosphorylation, NF?B p65 nuclear translocation, and NF?B binding were markedly attenuated in GRK5 ( -/- ) macrophages
Bhaskaran et al., Int J Mol Med 2010 : In RAW 264.7 macrophages, LPS induced DNA binding activity of RelA/p65 was significantly inhibited by chamomile, an effect that was mediated through the inhibition of IKKß, the upstream kinase regulating NF-?B/Rel activity, and degradation of inhibitory factor-?B
Song et al., Inflamm Res 2011 (MAP Kinase Signaling System) : LPS induced I?Ba phosphorylation/degradation and nuclear translocation of NF-?B/p65 were blocked by theaflavin
An et al., Int Immunopharmacol 2011 : Moreover, treatment with TA decreased LPS induced DNA binding of nuclear factor-kappa B ( NF-?B ) and nuclear translocation of p65 and p50 subunits of NF-?B
Kanoh et al., Chest 2011 (Bronchitis...) : LPS also induced NF-?B p65 phosphorylation, an effect that was inhibited by dapsone
Wang et al., Neurobiol Learn Mem 2011 (Inflammation) : Mechanistically, UA markedly inhibited LPS induced I?Ba phosphorylation and degradation, NF-?B p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt
Choi et al., Biol Pharm Bull 2011 : Furthermore, cornuside significantly attenuated the LPS stimulated phosphorylation and degradation of inhibitory kappa B-alpha and the subsequent translocation of the p65 subunit of nuclear factor-kappa B ( NF-?B ) to the nucleus
Song et al., BMC complementary and alternative medicine 2011 (Colitis...) : LPS induced I?Ba phosphorylation/degradation and nuclear translocation of NF-?B/p65 were blocked by BTE
Dou et al., Biol Pharm Bull 2011 : Moreover, Cha Fex significantly attenuated the LPS stimulated degradation of inhibitory kappa B-alpha and the subsequent translocation of the p65 subunit of nuclear factor-kappa B ( NF-?B ) to the nucleus
Lee et al., J Med Food 2011 : In further experiments, VLFEP considerably reduced the phosphorylation and degradation of inhibitory ?B as well as the translocation of nuclear transcription factor-?B ( NF-?B ) p65 into the nucleus, and its DNA binding was markedly induced by LPS stimulation
Lee et al., Exp Mol Med 2012 (Inflammation) : DK-139 blocked LPS induced phosphorylation of I?B and p65/RelA NF-?B, resulting in inhibition of the nuclear translocation and trans acting activity of NF-?B in BV2 microglial cells ... Inhibition of Akt abrogated LPS induced phosphorylation of p65/RelA , while overexpression of dominant- active p110CAAX enhanced p65/RelA phosphorylation as well as iNOS and COX2 expression
Yuan et al., Int J Biochem Cell Biol 2012 (Sepsis) : Chromatin immunoprecipitation assay confirmed that curcumin inhibits the binding of p65 to TREM-1 promoter in response to LPS
Byun et al., Biochem Biophys Res Commun 2012 (Inflammation) : In addition, EGCG treated DCs inhibited lipopolysaccharide (LPS) induced production of pro-inflammatory cytokines ( tumor necrosis factor [TNF ] -a, interleukin [ IL]-1ß, and IL-6 ) and activation of mitogen activated protein kinases ( MAPKs ), e.g., extracellular signal regulated kinase 1/2 ( ERK1/2 ), p38, c-Jun N-terminal kinase (JNK), and nuclear factor ?B ( NF-?B ) p65 translocation through 67LR
Piechota-Polanczyk et al., Gen Physiol Biophys 2012 : Neither ETA-R nor ETB-R blockers influenced LPS induced increase in p65 subunit level and activation of NF-?B pathway
Chang et al., J Cell Biochem 2013 : Consistent with the result of EMSA, LPS induced I?Ba phosphorylation and nuclear translocation of p65 were not inhibited by EX-4
Cheng et al., J Sci Food Agric 2013 (Inflammation) : In addition, PV suppressed the LPS induced p65 expression of nuclear factor ( NF ) -?B, which is associated with the inhibition of I?B-a degradation
Dilshara et al., Environ Toxicol Pharmacol 2013 (Inflammation) : Moreover, WH significantly suppressed the LPS induced DNA binding activity of nuclear factor-?B ( NF-?B ), as well as the nuclear translocation of the NF-?B subunits, p65 and p50 by suppressing of I?Ba phosphorylation and degradation
Bonaterra et al., Phytomedicine 2013 : In contrast to NSAIDs, STW 5 induced COX-1/COX-2, caspase-3 and Bax mRNA expressions in HT-29 and blocked LPS mediated translocation of the NF-?B p65 from the cytoplasm into the nucleus in PMA differentiated THP-1 macrophages
Zhu et al., Journal of biomedical research 2010 : IL-13 blocked LPS induced NF-?B subunit p65
Huang et al., Fertil Steril 2013 : LPS induced RANTES production and phosphorylation of p65 and I?B
Lee et al., Int Immunopharmacol 2013 : Furthermore, TMC suppressed tumor necrosis factor-a (TNF-a) and interleukin-1ß (IL-1ß) production, and the phosphorylation and degradation of I?B-a as well as the LPS stimulated nuclear translocation of p65 in macrophages
Zhao et al., PloS one 2013 : Nuclear factor-?B ( NF-?B ) activity, I?B degradation level and NF-?B/p65 nuclear translocation induced by lipopolysaccharide (LPS) and receptor activator for nuclear factor-?B ligand ( RANKL ) were markedly inhibited by pre-treatment with GSP
Oeth et al., Blood 1995 : These results indicated that salicylates inhibited LPS induction of TF gene transcription in monocytic cells by preventing nuclear translocation of c-Rel/p65 heterodimers
Nakano et al., Immunobiology 1993 : LPS induced p65 phosphorylation seems to be dependent on protein kinase C ( PKC ) and calmodulin (CaM), because it diminishes in the presence of inhibitors to PKC or CaM
Mackman et al., J Biol Chem 1994 : Taken together, these data indicated that inhibiting nuclear translocation of c-Rel/p65 heterodimers prevented LPS induction of TF gene transcription in monocytic cells
de Wit et al., Exp Hematol 1996 : Stimulation with LPS or IFN-gamma resulted in the expression of p50 and p65 subunits, while the combination of IFN-gamma plus LPS caused a further increase in the expression of NF-kappa B