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ADCYAP1 — PRKAR2A

Text-mined interactions from Literome

Shoge et al., Brain Res 1999 : Protection by PACAPs ( 100 nM ) against glutamate induced neurotoxicity was antagonized by PACAP6-38 ( 1 microM ), a PACAP antagonist, and H-89 ( 1 microM ), a protein kinase A (PKA) inhibitor
Zhou et al., Peptides 2001 : PACAP activates PKA , PKC and Ca ( 2+ ) signaling cascades in rat neuroepithelial cells
Danaher et al., J Neurovirol 2001 (Encephalitis, Herpes Simplex) : Taken together, PACAP induced HSV-1 activation from QIF-PC12 cells involves the PKA and possibly cAMP independent pathways
Obara et al., J Neurochem 2007 : We show that both Ras and Rap1 can be activated by cAMP or PACAP via protein kinase (PKA) dependent mechanisms
Bobrovskaya et al., Cell Signal 2007 : PACAP caused sustained activation of PKA , but did not sustain activation of other protein kinases including ERK, p38 kinase, PKC, MAPKAPK2 and MSK1
Wang et al., Am J Physiol Endocrinol Metab 2007 : Since our recent studies have shown that PACAP can induce GH secretion in carp pituitary cells through cAMP/PKA- and Ca2+/calmodulin dependent mechanisms, these results, taken together, suggest that alpha2-adrenergic stimulation in the carp pituitary may inhibit PACAP induced GH release and GH gene transcription by blocking the AC/cAMP/PKA pathway and Ca2+ entry through L-type VSCC
Xu et al., J Neurochem 2007 : H89, a protein kinase A (PKA) inhibitor attenuated the PACAP response
Markhotina et al., IET Nanobiotechnol 2007 : We confirmed the activation of PKA by PACAP in experiments where H89 also inhibited the PACAP induced relaxation
Harada et al., Biol Reprod 2007 : The MEK inhibitor, U0126, and the PKA inhibitors, H89 and cAMP dependent protein kinase peptide inhibitor ( PKI ), completely inhibited MAPK3/1 activation by either ADCYAP1 or CPT-cAMP ... These results suggest that in LbetaT2 cells, ADCYAP1 mainly increases Cga through activation of PKA and MAPK3/1, as well as through an additional unknown pathway
Cohen et al., BMC cancer 2010 (Cerebellar Neoplasms...) : PACAP and pharmacological activation of PKA also inhibited proliferation
Baxter et al., J Neurochem 2011 : Here, we show that in cortical neurons, PACAP induced PKA signaling exerts a major part of its neuroprotective effects indirectly, by triggering action potential ( AP ) firing
Ji et al., Hepatology 2013 (Liver Diseases...) : Conclusion : Our novel findings document the importance of PACAP mediated cAMP-PKA signaling in hepatic homeostasis and cytoprotection in vivo