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GRIP1 — PRKAR1A
Text-mined interactions from Literome
Hoang et al., J Biol Chem 2004
:
Here, we show that
GRIP1 is
regulated by cAMP dependent
protein kinase (PKA) that induces its degradation through the ubiquitin-proteasome pathway ... The proteasome inhibitors MG132 and lactacystin abolished the
PKA mediated degradation of
GRIP1 ... Using ts20 cells, a temperature-sensitive cell line that contains a thermolabile ubiquitin activating E1 enzyme, it was confirmed that
PKA mediated degradation of
GRIP1 is dependent upon the ubiquitin-proteasome pathway ... Finally, we show that
PKA regulates the intracellular distribution pattern of green fluorescent
protein-GRIP1 and stimulates recruitment of GRIP1 to subnuclear foci that are colocalized with the proteasome
Hoang et al., Endocrinology 2013
:
Here we show that the cAMP response element binding protein ( CREB ) downregulates GRIP1 and is necessary for the
PKA stimulated degradation of
GRIP1 , which leads to changes in the expression of a subset of genes regulated by estrogen receptor-a in MCF-7 breast cancer cells ... We propose that CREB mediates the
PKA stimulated degradation of
GRIP1 through protein-protein interaction and stimulation of proteasomal degradation of ubiquitinated GRIP1