Chen et al., Diabetologia 1999
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Interleukin-1beta increased the expression of adenine nucleotide translocator-1, phospholipase D-1 and cytokine induced neutrophil chemoattractant-1 and decreased expression of the protein tyrosine phosphatase-like protein IA-2
Tong et al., J Mol Neurosci 1999
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However, despite the ability of phorbol myristate acetate ( PMA ) to stimulate phospholipase D ( PLD ) and synthesis of phosphatidylethanol ( PEt ) in these cells, PLD activity was not affected by IL-1beta Chen et al., Endocrinology 2000
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Interleukin-1beta regulates phospholipase D-1 expression in rat pancreatic beta-cells
Park et al., Mol Pharmacol 2002
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The results of this study indicate that in human amnion cells, IL-1 beta might activate PLD through an upstream protein kinase C to elicit p38 and finally induce COX-2 expression