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CDC25A — PCNA

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• STRING interaction: CDC25A — PCNA (interaction, mapped from kegg_pathways)
• STRING interaction: PCNA — CDC25A (interaction, mapped from kegg_pathways)

Text-mined interactions from Literome

Blomberg et al., Mol Cell Biol 1999 : In vitro, Cdc25A dephosphorylates and activates the cyclin-Cdk complexes that are active during G ( 1 ) ... Overexpression of Cdc25A in the inducible system, however, leads to a premature activation of both cyclin E-Cdk2 and cyclin A-Cdk2 complexes, while no effect of cyclin D-dependent kinases is observed
Sandhu et al., Oncogene 2000 : Recombinant Cdc25A strongly reactivated cyclin E-cdk2 from senescent HMECs suggesting that reduction of Cdc25A contributes to cyclin E-cdk2 inhibition and G1 arrest at senescence ... In contrast, in the breast cancer derived MCF-7 line, Cdc25A overexpression increased both cyclin E-cdk2 activity and the S phase fraction
Jaime et al., Hepatology 2002 : In conclusion, premature translocation of CDC25A to the nucleus might be involved in the advanced induction of cyclin E/CDK2 activity and DNA replication in cells from animals lacking p21 ( Cip1 )
Chow et al., Mol Biol Cell 2003 : DNA damage during the spindle-assembly checkpoint degrades CDC25A , inhibits cyclin-CDC2 complexes, and reverses cells to interphase
Ray et al., Mol Cancer Ther 2007 (Prostatic Neoplasms) : Cdc25A dependent regulation of cyclin dependent kinase 2 (Cdk2) and changes in association of p21 ( WAF1/CIP1 ) and hSpy1 with Cdk2 resulted in inhibition of Cdk2 associated kinase activity
Yao et al., Toxicology 2008 : In the S-phase checkpoint induced by BaP the reduction of Cdc25A contributes to cyclin A inhibition
Solc et al., Dev Biol 2008 : CDC25A/B/C are dual-specificity phosphatases and activate cyclin dependent kinases (CDKs)
Pereg et al., Nat Cell Biol 2010 (Breast Neoplasms...) : The dual specificity ( Tyr/Thr ) phosphatase Cdc25A activates cyclin dependent kinases (Cdks) to promote cell-cycle progression and has significant oncogenic potential