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IL13 — IL18

Text-mined interactions from Literome

Hoshino et al., J Immunol 1999 : These results suggest IL-13 expression induced by IL-2 + IL-18 may be regulated by IFN-gamma in vivo, while IL-10 expression may be IFN-gamma independent
Yoshimoto et al., Proc Natl Acad Sci U S A 1999 (Hypersensitivity...) : Here we show that basophils and mast cells derived by culture of bone marrow cells with IL-3 for 10 days express IL-18Ralpha chain and that basophils produce large amounts of IL-4 and IL-13 in response to stimulation with IL-3 and IL-18 ... Injection of IL-12 and IL-18 inhibits IgE production in helminth infected wild-type mice and abolishes the capacity of their basophils to produce IL-4 and IL-13 in response to stimulation either with IL-3 and IL-18 or with FcepsilonR cross-linkage
Hoshino et al., Eur J Immunol 2000 : We have recently reported that IL-18 can induce IL-13 production in both NK cells and T cells in synergy with IL-2 but not IL-12, suggesting IL-18 can induce Th1 and Th2 cytokines when accompanied by the appropriate first signals for T cells
Nakanishi et al., Cytokine Growth Factor Rev 2001 (Arthritis, Rheumatoid...) : Moreover, IL-18 also induces IL-13 and/or IL-4 production by NK cells, mast cells and basophils
Helmby et al., J Exp Med 2001 (Chronic Disease...) : IL-18-deficient mice are highly resistant to chronic T. muris infection and in vivo treatment of normal mice with recombinant ( r ) IL-18 suppresses IL-13 and IL-4 secretion but does not affect IFN-gamma ... In vivo treatment of T. muris infected IFN-gamma-deficient mice with rIL-18 demonstrated that the inhibitory effect of IL-18 on IL-13 secretion is independent of IFN-gamma
Chakir et al., Cell Immunol 2001 : DX5+ splenocytes showed a rapid ( 6 h ) and sustained ( 6-72 h ) accumulation of IFN-gamma transcripts followed by a delayed ( 12-24 h ) up-regulation of IL-10 or IL-13 expression in response to IL-2 + IL-12 or IL-2 + IL-18 , respectively ... Last, we demonstrate that DX5+ cells respond to IL-18 independently of IL-12, as cells from both wild-type and IL-12Rbeta2KO mice produce IFN-gamma and IL-13 in response to IL-2 + IL-18
de la Barrera et al., Clin Exp Immunol 2004 (Leprosy) : mRNA coding for IFNgamma is induced by IL-18 and reduced in the presence of IL-13 , when PBMC from N or PB patients are stimulated with hsp65
Sugimoto et al., J Exp Med 2004 (Bronchial Hyperreactivity...) : Newly polarized Th1 cells and IFN-gamma expressing Th1 cells, both of which express IL-18 receptor alpha chain strongly, produce IFN-gamma, IL-9, IL-13 , granulocyte/macrophage colony stimulating factor, tumor necrosis factor alpha, regulated on activation, normal T cell expressed and secreted, and macrophage inflammatory protein 1alpha upon stimulation with Ag, IL-2, and IL-18 in vitro
Ngoumou et al., Cytokine 2004 : This study was performed to determine whether or not IL-18 is detectable in phytohemagglutinin ( PHA ) or betalactoglobulin ( BLG ) stimulated supernatants of cord blood mononuclear cells ( CBMC ) and to study the in vitro effect of IL-18 on the interferon ( IFN ) -gaamma and IL-13 release of CBMC of healthy neonates
Melk et al., Transplantation 2004 (Growth Disorders...) : During rhGH therapy in children with transplants, interleukin (IL)-2 production increased threefold at 4 weeks, and IL-4 and IL-13 increased by 70 % at 12 weeks
Rodriguez-Galán et al., J Immunol 2005 : Analysis of the thymic subsets, CD4 ( - ) CD8 ( - ) ( DN ), CD4 ( + ) CD8 ( + ), CD4 ( + ) CD8 ( - ), and CD4 ( - ) CD8 ( + ) revealed that IL-18 in combination with IL-2 or IL-12 induces IFN-gamma and IL-13 preferentially from DN cells ... The IL-2-plus-IL-18 or IL-12-plus-IL-18 effect on IFN-gamma and IL-13 expression is dependent on Stat4 and NF-kappaB but independent of Stat6, T-bet, or NFAT
Takahashi et al., Antimicrob Agents Chemother 2005 : In addition, ciprofloxacin suppressed the interleukin-18 induced production of tumor necrosis factor alpha, gamma interferon, and interleukin-12 in peripheral blood mononuclear cells by inhibiting the expression of intercellular adhesion molecule 1, B7.1, B7.2, and CD40 on monocytes, and this effect could be reversed by the addition of indomethacin or NS398
Yamanaka et al., Clin Cancer Res 2006 (Lymphoma, T-Cell, Cutaneous...) : In the absence of IL-12, IL-18 leads to increased immunoglobulin E production from B cells and enhanced production of IL-4 and IL-13 by basophils, mast cells, and CD4 ( + ) T cells
Liu et al., Eur J Immunol 2006 (Trichuriasis) : These results indicate that CD4+ T cells and NK cells are the major sources of IL-13 during the in vivo Th1 response induced by B7 blockade and that under these conditions, IL-18 is specifically required for the in vivo up-regulation of IL-13 production and associated host protection
Fujibayashi et al., Int J Mol Med 2007 : The combination of IL-18 and IL-12 induced IFN-gamma production in CB CD4+ V alpha 24+ NKT cells, while IL-18 in combination with IL-2 induced IL-13 production in these cells
Ho et al., J Leukoc Biol 2007 : We found that IL-33, but not IL-1beta or IL-18 , induced IL-13 and IL-6 production by mouse bone marrow derived, cultured mast cells ( BMCMCs ) independently of IgE ... In BMCMCs incubated with the potently cytokinergic SPE-7 IgE without specific antigen, IL-33, IL-1beta, and IL-18 each promoted IL-13 and IL-6 production, but the effects of IL-33 were more potent than those of IL-1beta or IL-18
Kondo et al., Int Immunol 2008 (Hyperplasia...) : Basophils, comprising IL-18Ralpha ( + ) cells ( 14.2 % ) and IL-33Ralpha ( + ) cells ( 34.6 % ), and mast cells, comprising IL-18Ralpha ( + ) cells ( 2.0 % ) and IL-33Ralpha ( + ) cells ( 95.6 % ), produce IL-4, IL-6, IL-13 , granulocyte macrophage colony stimulating factor ( GM-CSF ) and chemokines ( RANTES, MIP-1alpha, MIP-1beta and MCP-1 ), upon stimulation with IL-18 and/or IL-33 in the presence of IL-3
Haber et al., Exp Parasitol 2009 (Hyperalgesia...) : Leishmania major : interleukin-13 increases the infection induced hyperalgesia and the levels of interleukin-1beta and interleukin-12 in rats
Kroeger et al., J Leukoc Biol 2009 : Using mouse bone marrow derived cultured basophils, we found that IL-4 and IL-13 are produced in response to IL-18 or IL-33 stimulation
Blom et al., J Immunol 2012 (Inflammation) : IL-18 or IL-33 stimulation of Th1 cultures resulted in increased IFN-? and IL-13 production concurrent with reduced IL-10 gene transcription and secretion even though Th1 cultures, in contrast to IL-18Ra, had low ST2L expression
Sawada et al., PloS one 2013 (Asthma...) : We also demonstrate that IL-18 induces IFN-?, IL-13 , and eotaxin in the lungs of ovalbumin sensitized and challenged transgenic mice along with an increase in IL-13 producing CD4 ( + ) T cells
Junttila et al., J Allergy Clin Immunol 2013 : Basophils follow the same rule ; splenic basophils produce IL-13 in response to IL-18 or IL-33 plus IL-3