Gene interactions and pathways from curated databases and text-mining

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AKT1 — LOX

Text-mined interactions from Literome

Min et al., Cancer Res 2007 (Mammary Neoplasms, Experimental) : LOX-PP expression in Her-2/neu-driven breast cancer cells in culture suppressed Akt , extracellular signal regulated kinase, and nuclear factor-kappaB activation
Wu et al., Cancer Res 2007 (Lung Neoplasms...) : Similarly, LOX-PP expression in PANC-1 pancreatic cancer cells effectively reduced ERK and Akt activity and inhibited growth in soft agar and ability of these cells to migrate
Min et al., J Cell Biochem 2010 (Breast Neoplasms...) : In MIA PaCa-2 cells in culture, LOX-PP attenuated the ERK and AKT activities and decreased the levels of the NF-?B p65 and RelB subunits and cyclin D1, which are activated by RAS signaling
Voloshenyuk et al., Cytokine 2011 (MAP Kinase Signaling System) : Induction of cardiac fibroblast lysyl oxidase by TGF-ß1 requires PI3K/Akt , Smad3, and MAPK signaling
Ji et al., Int J Oncol 2013 (Neoplasm Invasiveness...) : Moreover, EOC cells display a marked increase in LOX dependent FAK/AKT activation and cell migration following hypoxia/reoxygenation