Channavajhala et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Moreover, Cot induced interleukin-8 production in HeLa cells is almost completely inhibited by the concurrent expression of hKSR-2 , whereas transforming growth factor beta activated kinase 1 ( TAK1 ) /TAK1 binding protein 1 (TAB1) induced interleukin-8 production is not affected by hKSR-2 co-expression
Channavajhala et al., Biochem Biophys Res Commun 2005
(Inflammation) :
We demonstrate that hKSR-2 is a negative regulator of MEKK3 mediated activation of MAP kinase ( specifically ERK and JNK ) and NF-kappaB pathways, and concurrently inhibits MEKK3 mediated interleukin-8 production