Snoeks et al., Infect Immun 2008
:
Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide induced interleukin-8 in intestinal HT-29 cells ... LPS induced IL-8 is increased in HT-29 cells with silenced Foxo3a ... In conclusion, LPS and bacterial infection inactivate Foxo3a in intestinal epithelia via the PI3K pathway and inactivated Foxo3a leads to the upregulation of IL-8 by suppressing inhibitory IkappaBalpha
Tabassam et al., Helicobacter 2012
(Helicobacter Infections) :
Akt, FoxO1 , or FoxO3a siRNA reduced H. pylori induced interleukin-8 production
Chakrabarty et al., Cancer Res 2013
:
These effects were associated with FoxO mediated inhibition of transcription of the antiapoptosis gene survivin ( BIRC5 ) and the CSC associated cytokine interleukin-8