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MAP3K1 — MMP9

Text-mined interactions from Literome

Rangaswami et al., J Biol Chem 2005 (Neoplasm Invasiveness) : To our knowledge this is first report that OPN induces NIK/MEKK1 mediated JNK1 dependent/independent AP-1 mediated pro-MMP-9 activation and regulates the negative crosstalk between NIK/ERK1/2 and MEKK1/JNK1 pathways that ultimately controls the cell motility, invasiveness, and tumor growth
Hammaker et al., Arthritis Res Ther 2007 (Arthritis, Rheumatoid) : Using either small interfering RNA ( siRNA ) knockdown or knockout fibroblast-like synoviocytes ( FLSs ), MEKK1 , MEKK2, or MEKK3 deficiency ( either alone or in combination ) had no effect on IL-1beta stimulated phospho-JNK ( P-JNK ) induction or MMP expression
Rangaswami et al., Oncol Rep 2007 (Lung Neoplasms...) : We examined the role of osteopontin (OPN) in NIK- and MEKK1 dependent MMP-9 activation, melanoma growth and lung metastasis and its clinical significance in malignant melanoma
Simon et al., Cancer Res 1998 (Carcinoma, Squamous Cell...) : In contrast, the activation of a transiently transfected wild-type MMP-9 promoter by MEKK-1 , a specific c-Jun NH2-terminal kinase activator, was only marginally inhibited by the compound, arguing for the specificity of SB 203580