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IRF6 — RNF19A
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Chen et al., Mol Pharmacol 1999
:
Thus,
activation of
p38 but not p44/42 MAPK by
LPS resulted in the stimulation of NF-kappaB-specific DNA-protein binding and the subsequent expression of inducible form of NO synthase and NO release in RAW 264.7 macrophages
Baldassare et al., J Immunol 1999
:
LPS stimulated
p38 MAPK activity in the RAW264.7 cells was blocked by SB203580, as measured by the inhibition of MAPKAP2 kinase activity, a downstream target of the p38 MAPK
Arbabi et al., J Immunol 1999
:
We examined the
effects of
LPS and ethanol on
p38 activation and the corresponding IL-8 and TNF-alpha production in human mononuclear cells
Nolan et al., Surgery 1999
:
LPS inhibited PMN apoptosis and
activated p38 and ERK in a dose- and time dependent fashion
Arbabi et al., Arch Surg 1999
:
Lipopolysaccharide (LPS) and PAF
activated p38 ... Although
LPS and PAF
activated p38 , only LPS induced IL-8 production ; PAF acted as a priming agent
Cario et al., J Immunol 2000
:
In contrast,
LPS did not significantly
induce activation of JNK and
p38 in CMT93 cells, p38 in T84 cells and MAPK and JNK in HT29 cells
Heagy et al., J Trauma 2000
(Inflammation...) :
Pretreatment of murine macrophages with LPS induces LPS-tolerance, with inhibition of
LPS stimulated activation of kinases ( ERK1/2 and
p38 ) and diminished release of tumor necrosis factor (TNF)
Ferlito et al., Shock 2001
(MAP Kinase Signaling System) :
LPS stimulated inhibitory kappa B alpha ( IkappaB alpha ) degradation and
p38 phosphorylation in CHO cells transfected with human CD14 receptor ( CHO-CD14 ), but not in CHO cells transfected with vector only
Chan et al., Am J Respir Cell Mol Biol 2001
(MAP Kinase Signaling System) :
By contrast, in the presence of 10 % serum, NAC had no effect on LPS activation of p42 and p44 ERK and in fact enhanced
LPS induction of
p38mapk and JNK phosphorylation
Nakamura et al., Proc Natl Acad Sci U S A 2001
:
Addressing the mechanism responsible for this suppression, we show that circulating Trx blocks ( i ) the
LPS stimulated in vitro activation of neutrophil
p38 mitogen activated protein kinase, ( ii ) the normal down-regulation of CD62L on neutrophils migrating into the LPS stimulated air pouch, and ( iii ) the in vitro adhesion of LPS activated neutrophils on endothelial cells
Han et al., Neurosci Lett 2002
:
LPS activated three MAPK subtypes, extracellular signal - regulated kinase ( ERK ),
p38 and c - Jun N - terminal kinase (JNK) as early as 15 min after stimulation
Tomaru Ki et al., J Mol Cell Cardiol 2002
(MAP Kinase Signaling System) :
In accordance with these results,
LPS increases phosphorylation of
p38 mitogen activated protein kinase ( MAPK )
Wang et al., Eur J Neurosci 2002
(Encephalitis...) :
Moreover,
LPS could
induce the activation of
p38 mitogen activated protein kinase ( MAPK ) and c-jun N-terminal kinase but not extracellular signal regulated kinase
Rosengart et al., Ann Surg 2003
(Multiple Organ Failure...) :
Nineteen patients were categorized into two groups according to baseline and
LPS stimulated
p38 activation in cells obtained by BAL
Ermert et al., Lab Invest 2003
(MAP Kinase Signaling System...) :
Moreover,
LPS induces or
increases phosphorylation of
p38 in other lung cell types
Lai et al., J Immunol 2003
:
Stimulation with
LPS resulted in the activation of the extracellular signal regulated kinase 1 and 2 ( ERK1/2 ) and mitogen activated kinase
p38
Carter et al., J Surg Res 2003
(Disease Models, Animal...) :
SB203580 inhibition of
p38 activity did not affect HSP72 expression, or reverse NaArs inhibition of
LPS induced TNF production
Wang et al., Hepatology 2004
(Endotoxemia...) :
Bilirubin had no effect on
LPS mediated activation of nuclear factor kappaB or
p38 mitogen activated protein kinase, consistent with a nuclear factor kappaB independent mechanism of action
Hosoi et al., Brain Res Mol Brain Res 2004
:
LPS induced
p38 MAP kinase phosphorylation was delayed in MyD88-deficient glial cells
Zhao et al., J Biol Chem 2005
(Inflammation...) :
Stimulation of primary alveolar macrophages isolated from MKP-1-deficient mice with
LPS resulted in a prolonged
p38 phosphorylation compared with wild type alveolar macrophages
Peng et al., Circulation 2005
(Cardiomyopathies) :
NADH oxidase activation by
LPS increased ERK1/2 and
p38 phosphorylation, and inhibition of ERK1/2 and p38 phosphorylation blocked the effect of NADH oxidase on TNF-alpha expression
Murakami et al., J Nutr 2005
(Neoplasms) :
Because SB203580 but not zerumbone suppressed
LPS induced
p38 MAPK activation, the molecular targets of zerumbone may be MAPK activated protein kinase-2 or located downstream
Grishin et al., J Immunol 2006
(Disease Models, Animal...) :
Previously, we described
LPS induced
p38 MAPK dependent expression of cyclooxygenase-2 (COX-2) in rat IEC-6 cells
Chen et al., Eur J Pharmacol 2006
:
Dipyridamole also inhibited
LPS stimulated
p38 mitogen activated protein kinase ( p38 MAPK ) and IkappaB kinase-beta (IKK-beta) activities in RAW 264.7 cells
Kim et al., Toxicology 2006
:
SB203580 substantially suppressed
LPS induced rises in
p38 MAPK phosphorylation, neutrophil recruitment, total protein content in bronchoalveolar lavage fluid, and apoptosis of bronchoalveolar cells
Drechsler et al., J Immunol 2006
:
LPS induced
phospho-p38 MAPK levels were augmented by ethanol treatment and the p38 inhibitor, SB203580, prevented both the ethanol induced increase in IL-10 production and the inhibitory effect of ethanol on TNF-alpha production
Schuster et al., Am J Physiol Lung Cell Mol Physiol 2007
:
LPS also
activated both
p38 and the HIF-1 pathway
Usluoglu et al., Eur J Immunol 2007
:
RIP2 mediates
LPS induced
p38 and IkappaBalpha signaling including IL-12 p40 expression in human monocyte derived dendritic cells
Hung et al., Pediatr Allergy Immunol 2007
:
The suppressive effect on MDC and IP-10 may, at least in part, involve the down-regulation of
LPS induced
p38 and ERK-MAPK expression
Handley et al., Int Immunol 2007
(MAP Kinase Signaling System) :
Inhibition of MLK activity using a pharmacological inhibitor, CEP11004, blocks
p38 and Jun N-terminal kinase (JNK) MAPK activation in
response to
LPS and poly ( I:C ), but not zymosan
Reimer et al., J Interferon Cytokine Res 2007
:
Whereas
LPS and VSV
induced the phosphorylation of
p38 and JNK, neither poly ( I:C ) nor Sendai virus led to the detection of phosphospecific signals
Saito et al., Eur J Pharmacol 2008
:
In vivo administration of docetaxel augmented
LPS induced
p38 activation but not extracellular signal related kinase ( ERK ) activation in isolated macrophages
Li et al., J Leukoc Biol 2008
(Inflammation) :
There was an equally diminished alpha-MSH suppression of
LPS stimulated intracellular activation of NF-kappaB and
p38 phosphorylation
Ahn et al., Arch Dermatol Res 2008
(MAP Kinase Signaling System) :
LPS induces melanogenesis through
p38 MAPK activation in human melanocytes
Kim et al., J Microbiol Biotechnol 2008
:
Further, and MEH protected against the
LPS induced activation of
p38 mitogen activated protein kinase
Fu et al., Eur Respir J 2009
(Inflammation) :
In vivo, concurrent amifostine administration inhibited
LPS induced oxidative stress and
p38 mitogen activated protein kinase activation, which was associated with reduced vascular leak and neutrophil recruitment to the lungs
Mi Jeong Sung et al., Int Immunopharmacol 2009
:
Vitisin A inhibited
LPS induced extracellular signal regulated kinase 1/2 ( ERK1/2 ) and
p38 phosphorylation and suppressed LPS induced NF-kappaB activation in RAW 264.7 cells
Kim et al., J Pharmacol Sci 2009
:
As a mechanism of action, MSA inhibited
LPS induced activation of NF-kappaB, ERK,
p38 , and JNK, which played pivotal roles in toll-like receptor 4-mediated DC maturation
Liu et al., Biochem Biophys Res Commun 2010
(Pulmonary Disease, Chronic Obstructive) :
Moreover, FGL2 knockdown in THP-1 cells significantly downregulated
LPS induced phosphorylation of
p38-MAPK while upregulating phosphorylation of c-Jun N-terminal kinase (JNK)
Koch et al., Neonatology 2011
:
We conclude that
p38 MAPK phosphorylation is crucially
involved in
LPS activation and could explain the differences in early cytokine response between neonatal and adult blood
Hu et al., Brain Res 2011
:
Moreover, Rg1 suppressed the phosphorylation level of I?B, nuclear translocation of p65 subunit of NF?B, and phosphorylation level of
p38 , ERK1/2, JNK mitogen activated protein kinase ( MAPK )
induced by
LPS
Rebola et al., J Neurochem 2011
:
The
LPS induced increases in phosphorylation of c-jun N-terminal kinase and
p38 and activation of caspase 3 were also prevented by SCH58261
Carchman et al., Hepatology 2011
(Liver Diseases) :
LPS induced phosphorylation of
p38 mitogen activated protein kinase ( p38 MAPK ), in part, via HO-dependent signaling
Wang et al., Neurobiol Learn Mem 2011
(Inflammation) :
Mechanistically, UA markedly inhibited
LPS induced I?Ba phosphorylation and degradation, NF-?B p65 nuclear translocation and
p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt
Zhan et al., Mol Biol Rep 2012
:
LPS treatment significantly
induced p38 MAPK activation, iNOS expression, and NO production, which could be attenuated by 2 µg/ml PHC pretreatment
Küper et al., American journal of physiology. Renal physiology 2012
:
LPS induced a TLR4 dependent stimulation of NF-?B and the MAPKs
p38 , ERK1/2, and JNK
Zhai et al., Mol Biol Rep 2012
(Glomerulonephritis, Membranoproliferative...) :
We demonstrated that PDTC inhibited LPS induced monocyte migration and attenuated
LPS induced
p38 MAPK activation
Kim et al., PloS one 2012
(Encephalitis) :
In LPS-responsive HEK293T cells, overexpression of the human LRRK2 pathologic, kinase-active mutant G2019S increased basal and
LPS induced levels of phosphorylated
p38 and JNK, whereas wild-type and other pathologic ( R1441C and G2385R ) or artificial kinase-dead ( D1994A ) LRRK2 mutants either enhanced or did not change basal and LPS induced p38 and JNK phosphorylation levels
Lee et al., Biochim Biophys Acta 2013
(Inflammation) :
Using measurements of nitric oxide release and inflammatory cytokine production, we provide the first verification of the anti-inflammatory activity and associated mechanism of an insect defensin, demonstrating that the anti-inflammatory actions of the defensin-like peptide, coprisin, are initiated by suppressing the binding of
LPS to toll-like receptor 4, and subsequently
inhibiting the phosphorylation of
p38 mitogen activated protein kinase and nuclear translocation of NF-kB
Lee et al., J Cell Biochem 2013
:
NaHS blocked nicotine and
LPS induced activation of
p38 , ERK, MKP-1, PI3K, PKC, and PKC isoenzymes, and NF-?B
Soliman et al., J Neuroimmune Pharmacol 2013
(Inflammation...) :
Further, we found that acetate treatment completely reversed
LPS induced phosphorylation of MAPK
p38 and decreased basal levels of phosphorylated extracellular signal regulated kinases1/2 ( ERK1/2 ) by 2-fold
Chang et al., Chem Biol Interact 2013
(Inflammation...) :
In addition, BGG mediated inhibition of AR prevented
LPS induced activation of JNK and
p38 and lowered ROS levels, which could inhibit LPS induced apoptosis
Edan et al., PloS one 2013
:
In the present study we found that administration of chemically modified tetracycline-3 ( COL-3 ), inhibits
lipopolysaccharide (LPS) induced microglial and
p38 MAPK
activation , as well as the increase in TNF-a, but not IL-1ß expression, in the brains of BALB/c mice
Lu et al., Neuroscience 2013
:
In cultured microglial cells, DHA dose-dependently reduced
lipopolysaccharide (LPS) induced phosphorylation of
p38 , production of proinflammatory cytokines ( TNF-a, IL-1ß, IL-6 ) and chemokines ( CCL2, CCL3 and CXCL10 )
Olajide et al., Evidence-based complementary and alternative medicine : eCAM 2013
:
Results also show that cryptolepine inhibited
LPS induced
p38 and MAPKAPK2 phosphorylation in the microglia
Sung et al., Pharm Biol 2013
:
The
LPS stimulated
p38 , JNK and ERK phosphorylations significantly more than the controls
Liu et al., J Immunol 2013
(MAP Kinase Signaling System) :
We also show that
LPS , through
p38 MAPK signaling,
induces phosphorylation of GRK2 at serine 670, which, in turn, suppresses GRK2 translocation to the membrane, thereby preventing GRK2 initiated internalization and desensitization of CCR2 in response to MCP-1
Wan et al., J Endocrinol 2013
:
DHT enhanced
LPS induced
p38MAPK , ERK1/2, and nuclear factor ?B pathway activation, which may contribute to the elevated expression of UCN1
Iliev et al., Fish Shellfish Immunol 2013
:
In the current study,
p38 phosphorylation was
induced by CpG oligonucleotides ( ODNs ) and
LPS in primary salmon mononuclear phagocytes
Han et al., J Biol Chem 1993
:
Pretreatment of 70Z/3-hCD14 cells with anti-hCD14 monoclonal antibody or the tyrosine kinase inhibitor herbimycin A inhibits
LPS induced tyrosine phosphorylation of
p38