Gene interactions and pathways from curated databases and text-mining

◀ Back to CASP8

CASP8 — COL1A1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: CASP8 → Complex of COL1A1-ITGA2-ITGB1 (decreases, COL1A1/ITGA2/ITGB1 Activity)
    Gendron et al., J Biol Chem 2003*
    Evidence: In experiments done in Jurkat T cells and activated peripheral blood T lymphocytes, engagement of alpha2beta1 integrin with collagen type I (Coll I) was found to significantly reduce Fas-induced apoptosis and caspase-8 activation
  • NCI Pathway Database Integrins in angiogenesis: Collagen (COL7A1/COL3A1/COL2A1/COL6A1/COL6A2/COL6A3/COL5A1/COL5A2/COL4A4_COL4A3_COL4A6_COL4A1_COL4A5/COL11A1/COL11A2/COL2A1/COL1A1/COL1A2) → Caspase 8 (CASP8) (modification, activates) Stupack et al., J Cell Biol 2001
    Evidence: mutant phenotype, assay, physical interaction