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CCR1 — CXCL17
Text-mined interactions from Literome
Schwartzkopff et al., Innate Immun 2012
(Inflammation) :
We report that the platelet derived CXC chemokine ligand 4 (
CXCL4 ), a known activator of human monocytes,
induces down-regulation of CC
chemokine receptors (CCR) 1 , -2, and -5, resulting in drastic impairment of monocyte chemotactic migration towards cognate CC chemokine ligands (CCL) for these receptors ... Interestingly,
CXCL4 mediated down-regulation of
CCR1 , CCR2 and CCR5 was strongly dependent on the chemokine 's ability to stimulate autocrine/paracrine release of TNF-a ... Interestingly,
CXCL4 mediated down-regulation of CCR1,
CCR2 and CCR5 was strongly dependent on the chemokine 's ability to stimulate autocrine/paracrine release of TNF-a ... Culture supernatants of CXCL4 stimulated monocytes as well as chemokine enriched preparations thereof reproduced
CXCL4 induced
CCR down-regulation
Lee et al., J Immunol 2012
:
CCR1 mediated STAT3 tyrosine phosphorylation and
CXCL8 expression in THP-1 macrophage-like cells involve pertussis toxin-insensitive Ga ( 14/16 ) signaling and IL-6 release