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ACAT1 — APOB

Text-mined interactions from Literome

Xu et al., J Biol Chem 1991 : In contrast, LDL stimulated ACAT only minimally at this level of lipoprotein-cholesterol influx
Tabas et al., J Biol Chem 1987 : We now report that when protein synthesis is inhibited in mouse peritoneal macrophages by treatment with cycloheximide, puromycin, or actinomycin D, native LDL induced whole-cell ACAT activity and CE accumulation is 10-fold higher than that seen in LDL treated control cells ... In contrast to the situation with mouse peritoneal macrophages, cycloheximide treatment of J774 macrophages, which under normal conditions display high ACAT activity and CE accumulation in the presence of native LDL , did not result in further enhancement of either ACAT activity or LDL induced CE accumulation
Tabas et al., J Clin Invest 1987 : In contrast, acetyl-LDL ( matched for degradation with LDL ) caused marked stimulation of ACAT activity in mouse peritoneal macrophages
Coetzee et al., Arteriosclerosis 1982 (Hyperlipoproteinemia Type II) : Fibroblasts from two cases ( CF and GM ) showed receptor activities which were approximately 10 % of the values obtained with normal cells, while ACAT stimulation by LDL was very low ... ACAT stimulation by LDL in cells from JG and ES was within the range of values shown by cells previously characterized as heterozygous for a receptor negative mutation ... ACAT stimulation by LDL was normal in cells from TT
Watanabe et al., Ann N Y Acad Sci 1995 (Arteriosclerosis) : M-CSF ( 100 ng/ml ) enhanced acidic and neutral CE hydrolase, and ACAT activities by 3.2-fold, 4-fold, and 2.3-fold, respectively, in the presence of acetyl LDL , and M-CSF increased ratios of both acidic and neutral CE hydrolase activities to ACAT activity
Okwu et al., J Lipid Res 1994 : When the sphingomyelin content of macrophages was increased by either incubation with exogenous sphingomyelin or ceramide ( a stimulator of endogenous sphingomyelin synthesis ), the ability of acetyl-LDL to stimulate whole-cell ACAT activity was substantially reduced despite similar lipoprotein uptake and total cholesterol accumulation as in control cells ... When the sphingomyelin content of macrophages was decreased by sphingomyelinase treatment, the ability of acetyl-LDL to stimulate whole-cell ACAT activity was enhanced despite no change in lipoprotein uptake
Oettl et al., Clin Chim Acta 1996 (Peroxisomal Disorders) : ACAT activity was measured in the absence and presence of exogenous LDL using [ 3H ] oleate as a substrate for cholesterol ester synthesis
Agbedana et al., Afr J Med Med Sci 1996 (Nephrotic Syndrome) : In addition, the effects of exogeneous cholesterol, 25-OH-cholesterol and low density lipoprotein (LDL) on the acyl-coenzyme A: cholesterol acyltransferase (ACAT) activity were investigated as well