Gene interactions and pathways from curated databases and text-mining

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BIRC2 — TNF

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Lee et al., J Biol Chem 1999 (Neoplasms) : PG490 also blocked TNF-alpha mediated induction of c-IAP2 ( hiap-1 ) and c-IAP1 ( hiap-2 ), members of the inhibitor of apoptosis (IAP) family
Furusu et al., Kidney Int 2001 : In response to TNF-alpha , expression of c-IAP1 and c-IAP2 was induced in HeLa cells and ECV304 endothelial cells, but not in mesangial cells
Imanishi et al., Clin Exp Pharmacol Physiol 2003 : Western blotting analysis indicated that TNF-alpha alone increased c-IAP1 protein levels, whereas CH11 alone had no effect
Yang et al., Invest Ophthalmol Vis Sci 2005 : Overexpression of mutant IkappaB blocked TNF-alpha induced TRAF-1, TRAF-2, c-IAP1 , c-IAP2, c-FLIP, and A1 gene expression and downregulated TRAF-1 protein levels
Wu et al., EMBO J 2005 : TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6 containing compartment and TRAF2 ubiquitination
Furusu et al., J Cell Physiol 2007 : In human endothelial cells, TNF-alpha induced c-IAP1 and c-IAP2, but not XIAP and TIAP/Survivin, at the transcriptional level ... In contrast, extracellular signal regulated kinase, p38 MAP kinase, and c-Jun N-terminal kinase were activated after stimulation with TNF-alpha, and inhibition of each kinase by PD098059, SB203580, curcumin, or SP600125 substantially attenuated the TNF-alpha induced c-IAP1 and c-IAP2 expression ... These data indicated that TNF-alpha induced expression of c-IAP1 and c-IAP2 via MAP kinases, but not via NF-kappaB, and that MAP kinases participated in the inhibition of apoptosis by induction of c-IAPs in TNF-alpha stimulated endothelial cells
Karrasch et al., PloS one 2007 (Colitis) : In vitro, luteolin sensitized colonic epithelial HT29 cells to TNFalpha induced apoptosis, caspase 3 activation, DNA fragmentation and reduced TNFalpha induced C-IAP1 , C-IAP2 and COX-2 gene expression
Dupoux et al., Blood 2009 : Here we show that, once in the cytoplasm, cIAP1 is involved in the degradation of the adaptor protein tumor necrosis factor receptor associated factor 2 ( TRAF2 ) by the proteosomal machinery
Park et al., Biochem Pharmacol 2011 (Inflammation...) : Triptolide also abrogated TNF induced expression of cell survival proteins ( XIAP, Bcl-x ( L ), Bcl-2, survivin, cIAP-1 and cIAP-2 ), cell proliferative proteins ( cyclin D1, c-myc and cyclooxygenase-2 ), and metastasis proteins ( ICAM-1 and MMP-9 )