◀ Back to TNF
BIRC2 — TNF
Pathways - manually collected, often from reviews:
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
cIAP1 (BIRC2)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP1 (BIRC2)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP1 (BIRC2)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP1 (BIRC2)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP2 (BIRC3)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP2 (BIRC3)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, activates)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
Caspase 8 (CASP8)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
→
Caspase 8 (tetramer) complex (CASP8)
(modification, inhibits)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
BIRC2
→
TNF
(indirect_complex)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Lee et al., J Biol Chem 1999
(Neoplasms) :
PG490 also blocked
TNF-alpha mediated
induction of c-IAP2 ( hiap-1 ) and
c-IAP1 ( hiap-2 ), members of the inhibitor of apoptosis (IAP) family
Furusu et al., Kidney Int 2001
:
In
response to
TNF-alpha , expression of
c-IAP1 and c-IAP2 was induced in HeLa cells and ECV304 endothelial cells, but not in mesangial cells
Imanishi et al., Clin Exp Pharmacol Physiol 2003
:
Western blotting analysis indicated that
TNF-alpha alone
increased c-IAP1 protein levels, whereas CH11 alone had no effect
Yang et al., Invest Ophthalmol Vis Sci 2005
:
Overexpression of mutant IkappaB blocked
TNF-alpha induced TRAF-1, TRAF-2,
c-IAP1 , c-IAP2, c-FLIP, and A1 gene expression and downregulated TRAF-1 protein levels
Wu et al., EMBO J 2005
:
TNF-alpha induced
c-IAP1/TRAF2 complex translocation to a Ubc6 containing compartment and TRAF2 ubiquitination
Furusu et al., J Cell Physiol 2007
:
In human endothelial cells,
TNF-alpha induced
c-IAP1 and c-IAP2, but not XIAP and TIAP/Survivin, at the transcriptional level ... In contrast, extracellular signal regulated kinase, p38 MAP kinase, and c-Jun N-terminal kinase were activated after stimulation with TNF-alpha, and inhibition of each kinase by PD098059, SB203580, curcumin, or SP600125 substantially attenuated the
TNF-alpha induced
c-IAP1 and c-IAP2 expression ... These data indicated that
TNF-alpha induced expression of
c-IAP1 and c-IAP2 via MAP kinases, but not via NF-kappaB, and that MAP kinases participated in the inhibition of apoptosis by induction of c-IAPs in TNF-alpha stimulated endothelial cells
Karrasch et al., PloS one 2007
(Colitis) :
In vitro, luteolin sensitized colonic epithelial HT29 cells to TNFalpha induced apoptosis, caspase 3 activation, DNA fragmentation and reduced
TNFalpha induced
C-IAP1 , C-IAP2 and COX-2 gene expression
Dupoux et al., Blood 2009
:
Here we show that, once in the cytoplasm,
cIAP1 is
involved in the degradation of the adaptor protein
tumor necrosis factor receptor associated factor 2 ( TRAF2 ) by the proteosomal machinery
Park et al., Biochem Pharmacol 2011
(Inflammation...) :
Triptolide also abrogated
TNF induced expression of cell survival proteins ( XIAP, Bcl-x ( L ), Bcl-2, survivin,
cIAP-1 and cIAP-2 ), cell proliferative proteins ( cyclin D1, c-myc and cyclooxygenase-2 ), and metastasis proteins ( ICAM-1 and MMP-9 )