◀ Back to TP53
SIAH1 — TP53
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
SIAH1
→
TP53
(increases, SIAH1 Activity)
Evidence: NF?B family transcription factors can induce expression of antiapoptotic proteins that oppose the intrinsic (Bcl-XL, Bfl-1), extrinsic (FLIP), and convergence (cIAP2) pathways (Figure 2A), as well as suppressing expression of the death inducer Bax (intrinsic pathway) in some types of tumor cells (Karin and Lin, 2002). Further, hyperactivity of NF?B is now well documented in certain cancers (Karin et al., 2002).
-
KEGG p53 signaling pathway:
TP53
→
SIAH1
(gene expression, expression)
-
KEGG p53 signaling pathway:
TP53
→
SIAH1
(gene expression, expression)
-
KEGG Wnt signaling pathway:
TP53
→
SIAH1
(protein-protein, indirect effect)
Text-mined interactions from Literome
Maeda et al., FEBS Lett 2002
:
Although it was reported that the expression of
Siah-1 is
induced by
p53 and p21/WAF1, little is known about the transcriptional regulation of the Siah-1 gene
Frew et al., Mol Cell Biol 2002
:
Siah1a and Siah1b were not
induced by activation of endogenous
p53 in tissues, primary murine embryonic fibroblasts ( MEFs ) or thymocytes
Fiucci et al., Proc Natl Acad Sci U S A 2004
:
We have previously found that the expression of human siah-1 and its mouse homologue
siah-1b are
induced by
p53 during apoptosis and tumor reversion ... In luciferase assays,
p53 induces a substantial
increase in
siah-1b promoter activity
Iwai et al., Oncogene 2004
:
Siah-1L , a novel transcript variant belonging to the human Siah family of proteins, regulates beta-catenin activity in a
p53 dependent manner
Carayol et al., Cell Signal 2006
:
The non-canonical pathway is mediated by
p53 induced
Siah-1 which is GSK-3beta phosphorylation independent
Fujita et al., Nat Cell Biol 2010
:
Experimental manipulation of p53 expression demonstrated that
p53 induces
Siah1 and represses TRF2 protein levels
Wang et al., Cancer Sci 2011
:
Hypoxia induced ß-catenin downregulation involves
p53 dependent activation of
Siah-1 ... Together, the results suggest that hypoxia downregulates ß-catenin by increasing
Siah-1 expression in a
p53 dependent manner
Grishina et al., Biochim Biophys Acta 2012
:
SIAH mediated ubiquitination and degradation of acetyl-transferases
regulate the
p53 response and protein acetylation