Machado-Vieira et al., Biol Psychiatry 2011
(Calcium Signaling) :
The Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-trisphosphate receptor mediated endoplasmic reticulum calcium release in subjects with bipolar disorder
Monaco et al., Cell Mol Life Sci 2013
(Calcium Signaling) :
Furthermore, distinct Bcl-2-family members may selectively regulate inositol 1,4,5-trisphosphate receptor ( IP3R ) : Bcl-2 likely acts as an endogenous inhibitor of the IP3R, preventing pro-apoptotic Ca ( 2+ ) transients, while Bcl-XL likely acts as an endogenous IP3R sensitizing protein promoting pro-survival Ca ( 2+ ) oscillations