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AKT3 — PIK3CG
Pathways - manually collected, often from reviews:
-
KEGG Apoptosis:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, indirect effect)
-
KEGG VEGF signaling pathway:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, compound)
-
KEGG Osteoclast differentiation:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, activation)
-
KEGG Focal adhesion:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, compound)
-
KEGG Jak-STAT signaling pathway:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, phosphorylation)
-
KEGG T cell receptor signaling pathway:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, compound)
-
KEGG B cell receptor signaling pathway:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein)
-
KEGG Fc gamma R-mediated phagocytosis:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, compound)
-
KEGG Neurotrophin signaling pathway:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, compound)
-
KEGG Cholinergic synapse:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, activation)
-
KEGG Chagas disease (American trypanosomiasis):
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, compound)
-
KEGG Measles:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, compound)
-
KEGG Influenza A:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, compound)
-
KEGG ErbB signaling pathway:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, compound)
-
KEGG Colorectal cancer:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, activation)
-
KEGG Renal cell carcinoma:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, indirect effect)
-
KEGG Prostate cancer:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, compound)
-
KEGG Melanoma:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, compound)
-
KEGG Chronic myeloid leukemia:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, compound)
-
KEGG Acute myeloid leukemia:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, compound)
-
KEGG Small cell lung cancer:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, compound)
-
KEGG Non-small cell lung cancer:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, compound)
-
KEGG Non-small cell lung cancer:
PIK3CA/PIK3CB/PIK3CD/PIK3CG
→
AKT1/AKT2/AKT3
(protein-protein, compound)
-
KEGG Chemokine signaling pathway:
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
→
AKT1/AKT2/AKT3
(protein-protein, compound)
-
WikiPathways Regulation of toll-like receptor signaling pathway:
PIK3R5/PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3
→
AKT3/AKT1/AKT2
(activation)
-
WikiPathways Toll-like Receptor Signaling Pathway:
PIK3R5/PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3
→
AKT3/AKT1/AKT2
(activation)
-
WikiPathways Chemokine signaling pathway:
PIK3CA/PIK3CD/PIK3R1/PIK3R2/PIK3R3/PIK3CG/PIK3R5/PIK3CB
→
AKT1/AKT2/AKT3
(activation)
Text-mined interactions from Literome
Hehl et al., Biochem J 2001
:
Expression of a constitutive active
PI3Kgamma ( PI3Kgamma-CAAX ) induced GVBD and
increased the levels of phosphorylated
Akt/protein kinase B and mitogen activated protein kinase ( MAPK )
Oudit et al., Circulation 2003
(Cardiomegaly...) :
The lack of
PI3Kgamma attenuated the activation of
Akt/protein kinase B and extracellular signal regulated kinase 1/2 signaling pathways in cardiac myocytes in response to isoproterenol
Vecchione et al., J Exp Med 2005
(Hypertension) :
Conversely,
PI3Kgamma was
necessary to activate protein kinase
B/Akt , which, in turn, enhanced L-type Ca ( 2+ ) channel mediated extracellular Ca ( 2+ ) entry
Kang et al., Proc Natl Acad Sci U S A 2006
(Cell Transformation, Neoplastic) :
The p110delta isoform constitutively activates the Akt signaling pathway ;
p110gamma activates
Akt only in the presence of serum
Guillermet-Guibert et al., Proc Natl Acad Sci U S A 2008
:
In macrophages, both p110beta and
p110gamma contributed to
Akt activation induced by the GPCR agonist complement 5a, but not by the Tyr kinase ligand colony stimulating factor-1
Canobbio et al., Blood 2009
:
However, PI3Kbeta, but not
PI3Kgamma , enzymatic activity was absolutely
required for
Akt phosphorylation, Rap1 activation, and platelet aggregation downstream of the immunoreceptor tyrosine based activation motif ( ITAM ) -bearing receptor glycoprotein VI (GPVI)
Haubner et al., PloS one 2010
(Myocardial Reperfusion Injury) :
Mechanistically,
PI3Kgamma is
required for activation of the Reperfusion Injury Salvage Kinase ( RISK ) pathway (
AKT/ERK1/2 ) and regulates phospholamban phosphorylation in the acute injury response