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AKT3 — IL1B

Text-mined interactions from Literome

Pousset et al., Eur Cytokine Netw 2000 : Furthermore, anti-inflammatory cytokines such as IL-4 and IL-10 that block IL-1b induced NFkappaB activation also attenuate IL-1beta induced Akt phosphorylation, despite the fact that IL-4 and IL-10 in isolation induced Akt phosphorylation
Zhang et al., Int J Oncol 2001 : Pretreatment with SB203085 inhibited IL-1beta induced p38 and AKT phosphorylation
Chen et al., J Biol Chem 2002 : In human embryonic kidney 293 cells, IL-1beta induces IkappaB kinase beta (IKKbeta) activation, IkappaBalpha degradation, NF-kappaB transactivation, and weak Akt activation ... CaMKKc and Akt overexpression decreases IRAK1 mediated NF-kappaB activity and its association with MyD88 in response to IL-1beta stimulation
Ruhul Amin et al., Oncogene 2002 : Exogenous expression of either SHPS-1 mutants that lack SHP-2 binding function or a dominant negative mutant of SHP-2 markedly inhibited the activation of Erk 1/2 and Akt by IL-1beta , whereas wild type SHPS-1 did not
Neumann et al., Eur J Immunol 2002 : IL-1beta induced phosphorylation of PKB/Akt depends on the presence of IRAK-1
Diem et al., Mol Cell Neurosci 2003 (Nerve Degeneration) : Western blot analysis revealed an IL-1 beta induced IL-1RI dependent upregulation of phospho-Akt
Li et al., Infect Immun 2003 : In a stable transfection system, dominant negative mutants of myeloid differentiation factor 88 ( MyD88 ) and interleukin-1 (IL-1) receptor associated kinase 1 ( IRAK-1 ) ( MyD88-TIR and IRAK-DD, respectively ) blocked Akt kinase activity in response to LPS and IL-1 beta ... A dominant negative mutant ( Mal-P/H ) of MyD88 adapter-like protein (Mal), a protein with homology to MyD88, failed to inhibit LPS- or IL-1 beta induced Akt activity
Amin et al., Int J Oncol 2003 : The PLC-PKC cascade is required for IL-1beta dependent Erk and Akt activation : their role in proliferation ... Pharmacological inhibition of the PLC-PKC cascade by using specific inhibitor for PLC-gamma ( U73122 ) and PKC ( GFX ) strongly inhibited IL-1beta induced Erk and Akt activation
Asehnoune et al., J Immunol 2004 : Antioxidant treatment of LPS stimulated neutrophils also inhibited the production of proinflammatory cytokines ( TNF-alpha, macrophage inflammatory protein-2, and IL-1beta ), as well as activation of the kinases IkappaB kinase alpha, IkappaB kinase beta, p38, Akt , and extracellular receptor activated kinases 1 and 2
Choi et al., FEBS Lett 2004 : Complete inhibition of interleukin (IL)-1beta induced Akt phosphorylation occurred at 50 microM LY29 or 100 nM WM
Jin et al., Acta Pharmacol Sin 2005 (Brain Diseases) : SF significantly prevented Abeta induced increases in IL-1beta and p38 MAPK activation and also Abeta induced changes in phospho-ERK and phospho-Akt/PKB expression levels
Chen et al., Proc Natl Acad Sci U S A 2006 (Aortic Diseases...) : PDGF/IL-1beta costimulation also induced a sustained phosphorylation of Akt and p70 ribosomal S6 kinase (p70S6K) ... The effects of PDGF/IL-1beta costimulation on contractile marker expression and Akt and p70S6K phosphorylation were blocked by the phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 and by adenovirus expressing a dominant negative Akt, and they were mimicked by constitutively active Akt
Chen et al., Biochem Pharmacol 2007 (Lung Neoplasms) : IL-1beta induced the activation of ERK, p38 MAPK, JNK, and AKT in A549 cells ... Pretreatment of cells with tangeretin inhibited IL-1beta induced p38 MAPK, JNK, and AKT phosphorylation and the downstream activation of NF-kappaB
Shakibaei et al., Biochem Pharmacol 2007 (Osteoarthritis) : Curcumin inhibited the IL-1beta induced stimulation of up-stream protein kinase B Akt
Lin et al., J Cell Physiol 2007 (Lung Neoplasms) : Src, PDGFR, and PI3K/Akt mediated the effects of IL-1beta because pretreatment with PP1, AG1296, and wortmannin also abrogated IL-1beta stimulated Src, PDGFR, and Akt phosphorylation, respectively
Xu et al., Rheumatology (Oxford) 2007 (Arthritis, Rheumatoid) : TNF-alpha induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta , IL-6 and IL-8 production induced by TNF-alpha
Tong et al., Neurobiol Aging 2008 : In trophic support deprived neurons, IL-1 beta compromised the PI3-K/Akt pathway mediated protection by BDNF and suppressed Akt activation
Jang et al., FEMS Immunol Med Microbiol 2007 : Interestingly, Dex attenuated IL-1beta mediated activation of p38 MAPK and JNK, but not of AKT
Venieratos et al., Cell Signal 2010 : These results indicated that glucose induced endogenous IL-1beta expression increased betaTC-6 cells apoptosis by inhibiting, at least in part, IRS-2/Akt mediated signalling through SOCS-1 upregulation
Xie et al., Clinical and vaccine immunology : CVI 2010 : IL-6 and TNF-alpha, but not IL-1beta , inhibited Akt phosphorylation within 15 min of insulin stimulation, but only IL-6 was inhibitory 30 min after stimulation
Zhang et al., J Pathol 2010 (Colitis...) : Our results showed that GDNF resulted in a significant reduction in enhanced permeability, inhibited MPO activity, IL-1beta and TNF-alpha expression, and increased ZO-1 and Akt expression