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SMAD5 — SP1

Pathways - manually collected, often from reviews:

• FastForward regulation: SP1 → SMAD5 (transcriptional regulation, unknown)
  Evidence: DNABINDING

Text-mined interactions from Literome

Jungert et al., Carcinogenesis 2006 (Pancreatic Neoplasms) : Moreover, inhibition of Sp1-DNA binding or transfection of Sp1-specific siRNA prevents TGFbeta induced Smad7 expression and consequently enhances Smad signaling in pancreatic cancer cells, as indicated by increased receptor mediated phosphorylation of Smad3
Ellman et al., Gene 2013 : The synergism results from LfcinB mediated activation of Sp1 and SMAD signaling pathways by ( i ) phosphorylation of SMAD 1/5/8 ; ( ii ) downregulation of SMAD inhibitory factors [ i.e., noggin and SMAD6 ( inhibitory SMAD ) ] ; and ( iii ) upregulation of SMAD4 ( universal co-SMAD )