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CYP3A4 — GP6

Text-mined interactions from Literome

Nowack et al., Nephrology (Carlton) 2008 : The interaction mechanisms of St. John 's Wort by pregnane X-receptor mediated upregulation of cytochrome-P450 enzyme 3A4 and p-glycoprotein expression and of grapefruit juice by mechanism based inhibition of intestinal CYP3A4 suggest that many other plant products will likewise cause interactions with drugs because they occupy the same metabolic pathways
, Prescrire Int 2012 (Melanoma...) : The potential for pharmacokinetic interactions is high : vemurafenib inhibits P-glycoprotein and CYP 1A2, and induces CYP 3A4