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HGF — JUN
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Rahmani et al., J Hepatol 1999
(Liver Neoplasms, Experimental) :
We have investigated whether
hepatocyte growth factor (HGF) induces differential
AP-1 responses in normal and transformed rat hepatocytes, the 7777 cells ...
HGF induced
AP-1 activation leads to the formation of distinct dimers with different functional capacities in normal and transformed hepatocytes
Gao et al., Hepatology 1999
:
HGF alone induced moderate levels of c-Jun-N-terminal kinase (JNK) and p44/p42 mitogen activated protein kinase ( MAPK ), resulting in moderate
levels of
AP-1-DNA binding activity ...
HGF alone
induced moderate levels of
c-Jun-N-terminal kinase (JNK) and p44/p42 mitogen activated protein kinase ( MAPK ), resulting in moderate levels of AP-1-DNA binding activity ... LPS may contribute to hepatocyte replication by potentiating the
effect of
HGF on the activation of both
AP-1-DNA binding and transcriptional activity
Seol et al., Oncogene 2000
(Carcinoma, Hepatocellular) :
Stimulation of Hepa 1-6 cells with
HGF resulted in a rapid and dramatic enhancement of the AP-1 binding activity as well as an overall increase in the level of
AP-1 protein
Olsen et al., Biochem J 2000
:
Involvement of
activator protein 1 complexes in the epithelium-specific activation of the laminin gamma2-chain gene promoter by
hepatocyte growth factor ( scatter factor )
GarcĂa-Trevijano et al., Gastroenterology 2002
:
Accordingly, we found that S-adenosylmethionine inhibits
hepatocyte growth factor induced cyclin D1 and D2 expression,
activator protein 1 induction , and hepatocyte proliferation
Bianchi et al., Arch Biochem Biophys 2002
(Melanoma, Experimental) :
Since in B16-F1 cells
HGF increased
AP-1 activity and the mRNA expression of various AP-1 subunits, we may conclude that HGF induced transcription of mouse ODC was largely due to triggering of AP-1 pathway
Kobayashi et al., Kidney Int 2003
:
Moreover, stimulation of the cells with
HGF resulted in a marked increase ( five- to tenfold ) in phosphorylation of extracellular signal related protein kinase ( ERK ) 1/2 and p38 mitogen activated protein kinase ( MAPK ), but not of
c-Jun NH2 terminal kinase (JNK)
Taniguchi et al., Mol Reprod Dev 2004
(MAP Kinase Signaling System) :
HGF enhanced the phosphorylation of Elk-1 and
c-Jun as nuclear transcription factors
Song et al., Hepatology 2007
:
HGF rapidly
induced c-Jun and small heterodimer partner mRNA and protein expression and increased phosphorylation of ERK1/2, JNK, and c-Jun ... Specific inhibitors of protein kinase C, extracellular signal regulated kinase 1/2 ( ERK1/2 ), and
c-Jun N-terminal kinase (JNK) blocked
HGF inhibition of CYP7A1 expression
Chen et al., PloS one 2012
:
HGF mediated
AP-1-luciferase activity and c-Jun binding to the AP-1 element was reduced by c-Met inhibitor, Ly294002, Akt inhibitor, and PP2
Rahimi et al., J Biol Chem 1996
:
However, wortmannin did not influence
HGF induced
c-Jun expression