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IL1B — NOS1

Text-mined interactions from Literome

Tu et al., J Hepatol 1999 : We have previously reported that the inflammatory cytokine interleukin-1beta (IL-1beta) induced the expression of the inducible nitric oxide synthase gene in primary cultured rat hepatocytes
Er et al., J Cataract Refract Surg 1999 : These findings suggest a strong inhibitory effect of NOS inhibitors and corticosteroids on aqueous levels of TNF-alpha and NO and no inhibitory effect on IL-1 beta and IL-6 levels after cataract surgery
Kaibori et al., J Hepatol 1999 : FK506 markedly inhibited the nitric oxide formation, inducible nitric oxide synthase protein synthesis and inducible nitric oxide synthase mRNA expression induced by interleukin 1beta , but cyclosporin A had no effects
Cain et al., Crit Care Med 1999 (Cardiomyopathies...) : We hypothesized the following : a ) TNF-alpha and IL-1beta directly depress human myocardial function ; b ) together, TNF-alpha and IL-1beta act synergistically to depress human myocardial function ; and c ) inhibition of ceramidase or nitric oxide synthase attenuates myocardial depression induced by TNF-alpha or IL-1beta by limiting proximal cytokine signaling or production of myocardial nitric oxide ( NO )
Kuo et al., Gastroenterology 2000 : Superoxide enhances interleukin 1beta mediated transcription of the hepatocyte-inducible nitric oxide synthase gene
Jiang et al., Hypertension 2000 (MAP Kinase Signaling System) : N-Acetyl-L-cysteine potentiates interleukin-1beta induction of nitric oxide synthase : role of p44/42 mitogen activated protein kinases
Chen et al., Diabetes 2000 (Insulinoma) : However, normal IL-1beta mediated translocation of NF-kappaB and induction of inducible nitric oxide synthase expression and nitric oxide production was severely impaired in the INS-1res cell lines, suggesting a mechanism for the IL-1beta resistance
Scholz-Pedretti et al., Br J Pharmacol 2000 : 4. Moreover, CGP-43182 completely blocked IL1beta induced gene expression of the inducible nitric oxide synthase , leading to an inhibition of cytokine stimulated nitric oxide formation
Gustafsson et al., Mol Pharmacol 2000 : beta-adrenergic stimulation of rat cardiac fibroblasts enhances induction of nitric-oxide synthase by interleukin-1beta via message stabilization
Carnovale et al., Fertil Steril 2001 : Aspirin dose dependently inhibits the interleukin-1 beta stimulated increase in inducible nitric oxide synthase , nitric oxide, and prostaglandin E ( 2 ) production in rat ovarian dispersates cultured in vitro
Tobai et al., J Obstet Gynaecol Res 2001 : To investigate the effect of IL-1beta, granulosa-luteal cells were cultured with various doses of IL-1beta ( 0, 0.05, 0.5, 5, 50, 100 ng/ml ), IL-1beta ( 5 ng/ml ) with NG-nitro-L-arginine-methyl ester ( L-NAME ), selective inhibitors of NOS , sodium nitroprusside ( SNP ), NO donors and Genistain, a tyrosine kinase inhibitor
Boyault et al., FEBS Lett 2001 : 15-deoxy-Delta12,14-prostaglandin J2 ( 15d-PGJ2 ), in contrast to troglitazone, was highly potent to counteract IL-1beta induced cyclooxygenase-2 and inductible nitric oxide synthase expression, NO production and the decrease in proteoglycan synthesis
Maeda et al., Anesthesiology 2001 : Halothane but not isoflurane attenuates interleukin 1beta induced nitric oxide synthase in vascular smooth muscle
Igwe et al., Neuroscience 2001 : Interleukin 1beta induced both nitric oxide synthase 2 (NOS-2) and cyclooxygenase 2 (COX-2) gene expression in dorsal root ganglion explant culture with increased NOS-2 and COX-2 activities, and corresponding increases in the production of nitric oxide and prostaglandin E ( 2 )
Gálvez et al., Aliment Pharmacol Ther 2001 (Chronic Disease...) : The intestinal anti-inflammatory effect of morin was accompanied by a significant reduction in colonic leukotriene B4 and interleukin-1beta levels, improvement in colonic oxidative stress and inhibition of colonic nitric oxide synthase activity
Gayle et al., Brain Res Dev Brain Res 2002 (Encephalitis...) : Inhibition of the inducible form of nitric oxide synthase ( iNOS ) by L-NIL did not affect LPS toxicity, but increased the LPS induced levels of both TNF-alpha and IL-1beta
Ribeiro et al., J Urol 2002 (Cystitis...) : The induction of inducible nitric oxide synthase in the urothelium appears to depend on the synergistic effect of IL-1beta and TNF-alpha
Hirafuji et al., Br J Pharmacol 2002 : Docosahexaenoic acid potentiates interleukin-1beta induction of nitric oxide synthase through mechanism involving p44/42 MAPK activation in rat vascular smooth muscle cells
Goodstone et al., Rheumatology (Oxford) 2002 : To compare the time- and concentration dependent effects of tumour necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta) on the induction of nitric oxide synthase (NOS) , the production of nitric oxide ( NO ) and the expression of aggrecan and hyaluronan ( HA ) in chondrocytes
Singh et al., Arthritis Rheum 2002 (Osteoarthritis, Knee) : Epigallocatechin-3-gallate inhibits interleukin-1beta induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes : suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB
Redd et al., Histochem J 2002 (Diabetes Mellitus, Type 1) : Interleukin-1beta in intra-islet macrophages may induce Fas and inducible nitric oxide synthase expression in an autocrine and paracrine manner and mediate beta cell destruction or even death of some macrophages and T cells
Ahmed et al., Free Radic Biol Med 2002 (Osteoarthritis) : Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1 beta induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes
Simi et al., J Neurochem 2002 : In contrast, chlomethiazole and SB203580 potently inhibited the IL-1beta induced expression of c-fos and inducible nitric oxide synthase , as monitored by northern blot and quantitative RT-PCR, respectively ... Because IL-1beta induced expression of c-fos and inducible nitric oxide synthase is believed to directly contribute to the pathology of cerebral ischaemic injury, the results suggest a direct mechanism for the neuroprotective effects of chlomethiazole and SB203580, and further establish the anti-inflammatory properties of chlomethiazole
Joly et al., Circ Res 1992 (Carotid Artery Injuries) : Balloon injury and interleukin-1 beta induce nitric oxide synthase activity in rat carotid arteries
Eizirik et al., FEBS Lett 1992 : Furthermore, IL-1 beta markedly increased the mRNA levels of the inducible macrophage form of nitric oxide synthase in HIT cells
Kim et al., Biochem Pharmacol 2004 : Inhibitory effects of epicatechin on interleukin-1beta induced inducible nitric oxide synthase expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-kappaB activation
Yang et al., J Biomed Sci 2004 : Heme oxygenase-1 attenuates interleukin-1beta induced nitric oxide synthase expression in vascular smooth muscle cells
Guikema et al., Free Radic Biol Med 2005 : Catalase potentiates interleukin-1beta induced expression of nitric oxide synthase in rat vascular smooth muscle cells
Ortega-Gutiérrez et al., FASEB J 2005 (Multiple Sclerosis) : Additionally, in microglial cells, UCM707 decreases the production of the proinflammatory cytokines tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta , and IL-6 ; reduces nitric oxide levels and inducible nitric oxide synthase expression ; and is able to potentiate the action of a subeffective dose of the endocannabinoid anandamide
Madrigal et al., J Neurosci Res 2005 : In the present report, we examined the role of IL-1beta in neurotoxicity induced by microglial conditioned media, and possible neuroprotective effects of NE. Incubation of cortical neurons with conditioned media ( CM ) obtained from lipopolysaccharide (LPS) treated microglia induced neuronal NOS2 expression and increased neuronal cell death, and these responses were reduced if the neurons were coincubated with interleukin-1 receptor antagonist
Kim et al., Toxicol In Vitro 2005 (Osteoarthritis) : Inhibitory effect of Buthus martensi Karsch extracts on interleukin-1beta induced expression of nitric oxide ( NO ) synthase and production of NO in human chondrocytes and LPS induced NO and prostaglandin E2 production in mouse peritoneal macrophages
Cragnolini et al., Neurosci Lett 2006 : Also, gamma-MSH ( 1 microg/microl ) eliminated the increase in NOS activity induced by IL-1beta
Richette et al., Ann Rheum Dis 2007 (Translocation, Genetic) : Oestrogens inhibit interleukin 1beta mediated nitric oxide synthase expression in articular chondrocytes through nuclear factor-kappa B impairment
Kawamura et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis) : IL-1beta induced expression and activation of inducible nitric oxide synthase and cyclooxygenase-2 were inhibited by apoE in vascular smooth muscle cells ( VSMCs )
Skorokhod et al., Malaria journal 2007 (Malaria) : Malarial pigment haemozoin, IFN-gamma, TNF-alpha, IL-1beta and LPS do not stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno purified human monocytes
Li et al., Arterioscler Thromb Vasc Biol 2007 (Inflammation) : FXR ligands induced smooth muscle cell death and downregulated interleukin (IL)-1beta induced inducible nitric oxide synthase and cyclooxygenase-2 expression
Chockalingam et al., Arthritis Rheum 2007 (Osteoarthritis) : Involvement of protein kinase Czeta in interleukin-1beta induction of ADAMTS-4 and type 2 nitric oxide synthase via NF-kappaB signaling in primary human osteoarthritic chondrocytes
Kang et al., Biol Pharm Bull 2008 : Troglitazone increases IL-1beta induced cyclooxygenase-2 and inducible nitric oxide synthase expression via enhanced phosphorylation of IkappaBalpha in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats
Lu et al., Zhonghua Yi Xue Za Zhi 2009 : [ Glutamine inhibits interleukin-1beta induced nitric oxide production and inducible nitric oxide synthase expression : experiment with cultured rat hepatocytes ]
Liang et al., Clin Orthop Relat Res 2010 (Disease Models, Animal...) : In vitro, muscone reversed IL-1beta induced upregulation of IL-1beta, tumor necrosis factor alpha, cyclooxygenase 2, inducible nitric oxide synthase , matrix metalloproteinase 13, aggrecanase 2, and nitric oxide and downregulation of Col2alpha1 and aggrecan
Susick et al., J Cell Mol Med 2009 : THS-78-5 was also able to attenuate IL-1beta induced inducible nitric oxide synthase expression and subsequent NO release
Xu et al., Zhonghua Yi Xue Za Zhi 2010 : Compared with uninfected control and Ad-eGFP infected group, Ad-mIL-10 infected group had decreased levels of NO and NOS induced by IL-1beta [ NO level ( nmol/10 ( 6 ) cells ) : 52.9 +/- 3.2 vs. 227.3 +/- 26.4, 235.1 +/- 28.6, both P < 0.05 ; NOS level ( U/10 ( 6 ) cells ) : 9.3 +/- 1.2 vs. 29.8 +/- 2.5, 30.5 +/- 2.8, both P < 0.05 ]
Sato et al., Mech Ageing Dev 1995 : Nitric oxide synthase (NOS) activity was enhanced in human umbilical vein endothelial cells ( HUVECs ) by the combined stimulation with IFN-gamma plus IL-1beta , TNF-alpha and LPS which was accompanied by cell death
Akabane et al., Biochem Biophys Res Commun 1995 : Nicotinamide inhibits IRF-1 mRNA induction and prevents IL-1 beta induced nitric oxide synthase expression in pancreatic beta cells
Kunz et al., Biochem Biophys Res Commun 1995 : Interleukin 1 beta induced expression of nitric oxide synthase in rat renal mesangial cells is suppressed by cyclosporin A
Scott-Burden et al., Biochem Biophys Res Commun 1993 : Growth factor regulation of interleukin-1 beta induced nitric oxide synthase and GTP : cyclohydrolase expression in cultured smooth muscle cells
Mühl et al., Eur J Pharmacol 1993 : Cyclosporin derivatives inhibit interleukin 1 beta induction of nitric oxide synthase in renal mesangial cells
Koide et al., Hypertension 1994 : These findings suggest that interferon gamma directly induces the expression of the inducible nitric oxide synthase gene, whereas tumor necrosis factor-alpha and interleukin-1 beta induce it, at least in part, via the induction of intermediary protein ( s ), and that transforming growth factor-beta 1 inhibits cytokine induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase
Kunz et al., Proc Natl Acad Sci U S A 1994 : Stimulation with IL-1 beta alone leads to an approximately 40-fold increase in NOS activity and nitrite synthesis, whereas the elevation of cAMP with forskolin, cholera toxin, salbutamol, or dibutyryl-cAMP for 24 h resulted in a 2- to 12-fold increase in NOS activity ... IL-1 beta increased NOS mRNA levels in a dose- and time dependent fashion with a peak of NOS mRNA at 24 h. Dibutyryl-cAMP also increased NOS mRNA levels in mesangial cells in a dose- and time dependent manner
Tsujino et al., Circulation 1994 : Induction of nitric oxide synthase gene by interleukin-1 beta in cultured rat cardiocytes
Yan et al., J Immunol 1994 : In addition, NOS activity was not induced in PMNs by LPS, IL-1 beta , or IFN-gamma
Durante et al., Thromb Res 1994 : Cyclic nucleotide regulation of interleukin-1 beta induced nitric oxide synthase expression in vascular smooth muscle cells
Mühl et al., Biochem J 1994 : Possible role of protein kinase C-epsilon isoenzyme in inhibition of interleukin 1 beta induction of nitric oxide synthase in rat renal mesangial cells
Tetsuka et al., Proc Natl Acad Sci U S A 1994 : The inflammatory cytokine interleukin 1 beta (IL-1 beta) induces both cyclooxygenase (COX) and nitric oxide synthase (NOS) with increases in the release of prostaglandin ( PG ) and nitric oxide ( NO ) by mesangial cells
Kanno et al., Am J Physiol 1994 : Regulation of inducible nitric oxide synthase gene by interleukin-1 beta in rat vascular endothelial cells
Murrell et al., Biochem Biophys Res Commun 1995 : The inflammatory mediators interleukin-1 beta (IL-1 beta) , tumor necrosis factor-alpha (TNF-alpha) and the bacterial cell wall fragment endotoxin, induced both nitric oxide synthase activity and stromelysin and collagenase activity in whole cell preparations and in conditioned media from explants of bovine and human cartilage
Schini-Kerth et al., Eur J Pharmacol 1994 : These observations suggest that pyrrolidine dithiocarbamate prevents the interleukin-1 beta mediated expression of the inducible nitric oxide synthase without affecting the activity of the constitutive enzyme in the rat aorta
Park et al., J Neurosci Res 1994 (Glioma) : The NOS activity induced by LPS in C6 cells was maximal at 4 to 8 hr and then rapidly decreased, while NOS activity induced by IL-1 beta/IFN-gamma slowly decreased after 4 hr
Hirokawa et al., Br J Pharmacol 1994 : 1. These studies examine the effect of retinoids on interleukin 1 beta (IL-1 beta) induced nitric oxide synthase (NOS) activity in cultured rat aortic vascular smooth muscle ( VSM ) cells and isolated rat aortic rings
Durante et al., Biochem J 1995 : Ethanol potentiates interleukin-1 beta stimulated inducible nitric oxide synthase expression in cultured vascular smooth muscle cells
Bedoya et al., Biochem Biophys Res Commun 1995 (Insulinoma...) : We presently investigated the effects of pyrrolidine dithiocarbamate ( PDTC ), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase ( iNOS ) and manganese superoxide dismutase ( MnSOD ) mRNAs by IL-1 beta in insulin producing RIN cells
Kwon et al., Endocrinology 1995 (Insulinoma...) : Interleukin-1 beta induced nitric oxide synthase expression by rat pancreatic beta-cells : evidence for the involvement of nuclear factor kappa B in the signaling mechanism
Geller et al., J Immunol 1995 : A central role for IL-1 beta in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase
Eizirik et al., FEBS Lett 1993 : Moreover, the stimulatory effects of recombinant IL-1 beta on NOS mRNA expression are prevented by co-incubation with an inhibitor of gene transcription ( actinomycin D ) or an inhibitor of protein synthesis ( cycloheximide ) ... These data suggest that IL-1 beta induced NOS mRNA expression may be mediated by transcription of immediate early response genes, and that c-fos may be one of these genes
Kanno et al., Hypertension 1993 : These data demonstrate for the first time that interleukin-1 beta induces gene expression of inducible nitric oxide synthase and its de novo protein synthesis in rat vascular smooth muscle cells, thereby leading to generation of nitric oxide via Ca2+/calmodulin independent and protein kinase C-independent mechanisms
Malinski et al., Biochem Biophys Res Commun 1993 (Hypertension) : Endothelial cell nitric oxide synthase ( the constitutive enzyme ) was stimulated with bradykinin, and vascular smooth muscle cell nitric oxide synthase ( the inducible enzyme ) was induced with interleukin-1 beta
Kapur et al., Proc Natl Acad Sci U S A 1993 : IL-1 beta resulting from cleavage of pIL-1 beta by SPE B induced nitric oxide synthase activity in vascular smooth muscle cells and killed of the human melanoma A375 line
Lee et al., J Neuroimmunol 1993 : Induction of nitric oxide synthase activity in human astrocytes by interleukin-1 beta and interferon-gamma
Suzuki et al., J Neurosurg 1994 : This study further examines these questions by investigating the effects of Hb on the induction of NOS by IL-1 beta
Delaney et al., FEBS Lett 1993 : Damage also resulted following induction of nitric oxide synthase by the cytokine interleukin-1 beta in both islets and HIT-T15 cells and was prevented by replacing the substrate, arginine, with nitromonomethyl arginine ... Thus intracellular levels of nitric oxide generated by interleukin-1 beta induced nitric oxide synthase were sufficient to cause DNA damage in islet cells and HIT-T15 cells
Corbett et al., FASEB J 1993 : The purpose of this investigation was to determine if brief exposures of islets to IL-1 beta are sufficient to induce the formation of nitric oxide and to examine the signaling process associated with IL-1 beta induced expression of nitric oxide synthase
Redmond et al., J Cell Physiol 1996 : In addition, the cytokine interleukin 1 beta (IL-1 beta) which induced NOS activity with subsequent NO synthesis in vascular smooth muscle, also caused a similar upregulation of ET receptors
LaPointe et al., Hypertension 1996 : Mechanisms of interleukin-1beta regulation of nitric oxide synthase in cardiac myocytes
Perrella et al., J Biol Chem 1996 : Suppression of interleukin-1beta induced nitric-oxide synthase promoter/enhancer activity by transforming growth factor-beta1 in vascular smooth muscle cells
Kitade et al., Hepatology 1996 : Furthermore, IL-1 beta markedly increased NOS activity, and this increase in activity was accompanied by the expression of inducible NOS (iNOS) messenger RNA ( mRNA )
Duval et al., Mol Pharmacol 1996 : Induction of hepatic nitric oxide synthase (NOS) by tumor necrosis factor-alpha (TNF alpha), interleukin-1 beta (IL-1 beta) , interferon-gamma (IFN gamma), interleukin-6 (IL-6), and lipopolysaccharide was assessed as activity and immunoreactive protein
Manfield et al., Inflamm Res 1996 : Here we show that in cultured bovine chondrocytes and explants of human osteoarthritic cartilage both nitric oxide synthase and cyclooxygenase activities were induced by the inflammatory mediators, lipopolysaccharide, and interleukin-1 beta or tumor necrosis factor-alpha
Romero et al., Am J Physiol 1996 : The results indicate that LPS induction of NOS activity in brain cells is mediated in part by both IL-1 beta and TNF-alpha
Amin et al., Proc Natl Acad Sci U S A 1996 (Arthritis, Rheumatoid...) : Among the tetracycline group of compounds, doxycycline > minocycline blocked and reversed both spontaneous and interleukin 1 beta induced OA-NOS activity in ex vivo conditions
Tabraue et al., Endocrinology 1997 : Induction of guanosine triphosphate-cyclohydrolase by follicle stimulating hormone enhances interleukin-1 beta stimulated nitric oxide synthase activity in granulosa cells ... Treatment with the GTPCH inhibitor 2,4-diamino-6-hydroxypyrimidine prevented IL-1 beta induced NOS activity in untreated or FSH stimulated cells, and this inhibition was completely reversed by sepiapterin, a substrate for BH4 biosynthesis, via an alternative pterin salvage pathway present in many cell types
Ding et al., Mol Psychiatry 1997 : Cultures of human fetal astrocytes and microglia produce inducible nitric oxide synthase and nitric oxide in response to Interferon gamma and Interleukin 1 beta
Finder et al., J Biol Chem 1997 : In this study, we describe the opposing effects of these inhibitors on interleukin-1beta (IL-1beta) stimulated induction of nitric-oxide synthase-2 (NOS-2) in rat pulmonary artery smooth muscle cells ( RPASMC ) and rat hepatocytes
Gansauge et al., FEBS Lett 1997 : Induction of inducible nitric oxide synthase by tumor necrosis factor-alpha, interferon-gamma and interleukin-1beta inhibited cell proliferation and led to a G1 arrest
Kunz et al., Inflamm Res 1997 : Transforming growth factor-beta 2 inhibits interleukin 1 beta induced expression of inducible nitric oxide synthase in rat renal mesangial cells
Hauber et al., Cell Immunol 1997 : We show that gene expression of IL-1 alpha, IL-1 beta , IL-6, granulocyte-colony stimulating factor, and IL-10 was induced in both cell fractions, whereas increased mRNA levels of interferon-gamma and the inducible nitric oxide synthase were exclusively detected in the patients ' nonadherent MNCs
Montón et al., Hypertension 1997 : Exogenous angiotensin II inhibited IL-1beta stimulated inducible nitric oxide synthase protein expression in both deendothelialized vessels and those with endothelium, although with reduced ability on the aortic segments with endothelium by a nitric oxide independent mechanism ... In the aortic rings with endothelium, either inhibition of the AT-1 receptor with losartan or blocking of angiotensin II generation with fosinopril enhanced interleukin-1beta stimulated inducible nitric oxide synthase protein expression
Mabley et al., FEBS Lett 1997 : Insulin-like growth factor I reverses interleukin-1beta inhibition of insulin secretion, induction of nitric oxide synthase and cytokine mediated apoptosis in rat islets of Langerhans
Muniyappa et al., Hypertension 1998 : IL-1beta stimulated [ 3H ] citrulline forming activity of the nitric oxide synthase (NOS) was also significantly lower in high-glucose exposed cells, and this was reflected in diminished cellular levels of NOS protein ... Increasing intracellular calcium by A23187, an ionophore or thapsigargin, an inhibitor of endoplasmic reticulum Ca2+-ATPase, significantly decreased IL-1beta induced NO release and NOS expression ... These results indicate that glucose induced inhibition of IL-1beta stimulated NO release and NOS expression may be mediated by PKC activation and increased intracellular calcium
Weber et al., Br J Pharmacol 1998 : Inhibition of glycosphingolipid synthesis by threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol ( PDMP ) and the modulation of IL-1beta stimulated expression of inducible nitric oxide synthase in rat aortic smooth muscle cells
Newton et al., Eur J Biochem 1998 (Inflammation) : However, in these cells, IL-1beta induction of inducible nitric oxide synthase , granulocyte-macrophage colony stimulating factor and cyclooxygenase-2 mRNA showed 70-90 % repression by dexamethsone
LaPointe et al., Hypertension 1999 : Interleukin-1beta regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes