Gene interactions and pathways from curated databases and text-mining

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IL8 — PLA2G4A

Text-mined interactions from Literome

Pawliczak et al., J Biol Chem 2004 : cPLA2 overexpression and activation increased both IL-8 and COX-2 reporter gene activity
Lefebvre et al., FASEB J 2010 : As negative controls, interleukin-8- and formyl-methionyl-leucyl-phenylalanine elicited migration in vitro was not inhibited either by an LTB ( 4 ) receptor antagonist or by the cPLA(2)alpha inhibitor
Borot et al., PloS one 2009 : DRM destabilizing agent methyl-beta-cyclodextrin induced further cPLA2alpha activation and eicosanoid release, but inhibited IL-8 synthesis
Chi et al., Arthritis Rheum 2011 (Arthritis, Rheumatoid) : Cytosolic phospholipase A2 induction and prostaglandin E2 release by interleukin-1ß via the myeloid differentiation factor 88-dependent pathway and cooperation of p300, Akt, and NF-?B activity in human rheumatoid arthritis synovial fibroblasts