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IL6 — MAP2K4

Text-mined interactions from Literome

Schuringa et al., Biochem J 2000 (Carcinoma, Hepatocellular...) : However, SEK-1/MKK-4 [ where SEK-1 stands for stress activated protein kinase ( SAPK)/ERK kinase 1, and MKK-4 stands for MAP kinase kinase 4 ] was activated in response to IL-6 and overexpression of dominant negative SEK-1/MKK-4 ( A-L ) reduced both IL-6 induced STAT3 Ser ( 727 ) phosphorylation as well as STAT3 transactivation
Schuringa et al., J Biol Chem 2001 : PKCdelta signals downstream of Rac-1 and SEK-1/MKK-4, because enhanced STAT3 transactivation induced by overexpression of constitutive active RacV12 was strongly abrogated by rottlerin, whereas IL-6 induced SEK-1/MKK-4 Thr-223 phosphorylation was not affected under these conditions
Gobert et al., J Biol Chem 2004 : In contrast, inhibitors of protein kinase A or C, mitogen activated protein kinase kinase , and phosphoinositide 3-kinase had no effect on IL-6 mRNA levels
Yang et al., Microvasc Res 2009 (AIDS Dementia Complex) : Inhibitors of STAT1, mitogen activated protein kinase kinase ( MEK ) ( PD98059 ), and phosphatidyl inositol 3 kinase (PI3K) ( LY294002 ), blocked gp120 induced STAT1 activation and significantly diminished IL-8-, IL-6- , and gp120 induced monocyte adhesion and migration across in vitro BBB models
Kulas et al., J Biol Chem 1996 : While expression of CD45 was associated with a decrease in the responsiveness of early insulin receptor signaling, interleukin 6-dependent activation of mitogen activated protein kinase kinase and mitogen activated protein kinase was equivalent between CD45- and CD45+ cells
Bode et al., J Hepatol 1998 : The mitogen activated protein kinase-kinase inhibitor PD 098059 abolished phosphorylation of the extracellular signal regulated kinases-1 and -2 in response to lipopolysaccharide, irrespective of the medium osmolarity, and diminished lipopolysaccharide induced interleukin-6 mRNA expression and interleukin-6 production under normo- and hypoosmotic conditions by about 50 % ; it also resulted under hyperosmotic conditions in an about 80 % inhibition