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CCND3 — CDKN1A

Pathways - manually collected, often from reviews:

• KEGG Cell cycle: CDKN1A → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG p53 signaling pathway: CDKN1A → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: CDKN1A — CCND3 Ramachandran et al., Science 2004
• IRef Bind_translation Interaction: CDKN1A — CCND3 (array technology) Ramachandran et al., Science 2004
• IRef Biogrid Interaction: CDKN1A — CCND3 (direct interaction, two hybrid) Rual et al., Nature 2005
• IRef Biogrid Interaction: CDKN1A — CCND3 (physical association, affinity chromatography technology) Datta et al., Cell Growth Differ 1998
• IRef Biogrid Interaction: CDKN1A — CCND3 (direct interaction, pull down) Chen et al., Mol Cell Biol 1996
• IRef Biogrid Interaction: CDKN1A — CCND3 (direct interaction, pull down) Ramachandran et al., Science 2004
• IRef Biogrid Interaction: CDKN1A — CCND3 (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
• MIPS CORUM Cell cycle kinase complex CDK5: Cell cycle kinase complex CDK5 complex (CCND1-CCND3-CDK5-CDKN1A-PCNA) Zhang et al., Mol Biol Cell 1993
• MIPS CORUM CyclinD3-CDK4-CDK6-p21 complex: CyclinD3-CDK4-CDK6-p21 complex complex (CCND3-CDK4-CDK6-CDKN1A) Wang et al., Cell Growth Differ 1996*
• IRef Corum Interaction: Complex of CDKN1A-CDK4-CCND3-CDK6 (association, anti tag coimmunoprecipitation) Wang et al., Cell Growth Differ 1996*
• IRef Corum Interaction: Complex of CCND1-PCNA-CCND3-CDK5-CDKN1A (association, anti bait coimmunoprecipitation) Zhang et al., Mol Biol Cell 1993
• IRef Hprd Interaction: CDKN1A — CCND3 (in vitro) Ramachandran et al., Science 2004
• IRef Intact Interaction: Complex of CDK14-CCND3-CDKN1A (association, anti tag coimmunoprecipitation) Shu et al., Proc Natl Acad Sci U S A 2007*
• IRef Intact Interaction: Complex of 15 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Intact Interaction: Complex of 27 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: CDKN1A — CCND3 (physical association, two hybrid pooling approach) Rual et al., Nature 2005
• IRef Intact Interaction: CDKN1A — CCND3 (physical association, two hybrid array) Wang et al., Molecular systems biology 2011
• IRef Intact Interaction: CDKN1A — CCND3 (direct interaction, protein array) Ramachandran et al., Science 2004
• IRef Ophid Interaction: CDKN1A — CCND3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Schönthal et al., Exp Eye Res 1999 : However, the growth-inhibitory status of these components is clearly reversible : upon transduction with large T antigen, the expression of cyclin A, cyclin D , cdk2, and cdk4 is induced , whereas the expression of p21 and p27 is inhibited, and the cells proliferate
Hoque et al., Cancer Epidemiol Biomarkers Prev 2008 (Prostatic Neoplasms) : Both statins suppressed expression of Rb, phosphorylated Rb, cyclin D1, cyclin D3 , CDK4, and CDK6, but induced p21 and p27 expression in prostate cancer cells
Chan et al., J Pathol 2008 (Carcinoma, Squamous Cell...) : This inhibitory phenomenon was associated with the reduced expressions of cyclin B1, cyclinD1 and cdc25B but increased expression of p27 ( Kip1 ) and p21 ( Cip1 )