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E2F2 — MYLIP
Text-mined interactions from Literome
Aguda et al., Proc Natl Acad Sci U S A 2008
(Neoplasms) :
In return,
E2F and Myc
induce the transcription of
miR-17-92 , thus forming a negative feedback loop in the interaction network
Lal et al., Mol Cell 2009
:
miR-24 directly
regulates MYC and
E2F2 and some genes that they transactivate ... In fact,
miR-24 regulates expression of
E2F2 , MYC, AURKB, CCNA2, CDC2, CDK4, and FEN1 by recognizing seedless but highly complementary sequences
Noguchi et al., J Biol Chem 2012
(Melanoma) :
The ectopic expression of
miR-203 in melanoma cells
reduced the levels of E2F3a,
E2F3b , and ZBP-89 protein expression
Wu et al., FEBS Lett 2012
(Glioblastoma) :
miR-125b regulates the proliferation of glioblastoma stem cells by targeting
E2F2 ... Furthermore, two binding sites for miR-125b are identified in the 3'UTR of E2F2 and overexpression of
miR-125b in CD133 positive GSCs
represses the endogenous level of
E2F2 protein
Yan et al., PloS one 2012
:
In turn,
E2F is
inhibited by
miR449 through regulating different transcripts, thus forming negative feedback loops in the interaction network