Gene interactions and pathways from curated databases and text-mining

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IL5 — POT1

Text-mined interactions from Literome

Yamada et al., Anticancer Res 2002 (Stomach Neoplasms) : TRF1, TRF2 and TIN2 are negative regulators of telomere length, while tankyrase and Rap1 act as positive regulators
Ye et al., J Biol Chem 2004 : TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres
Kendellen et al., Mol Cell Biol 2009 : Mechanistically, expression of POT1 ( DeltaOB ) reduced the association of TRF2 with POT1, RAP1, and TIN2 ; however, of these proteins, only ectopic expression of POT1 suppressed the telomere elongation induced by POT1 ( DeltaOB )