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IL5 — POT1
Text-mined interactions from Literome
Yamada et al., Anticancer Res 2002
(Stomach Neoplasms) :
TRF1,
TRF2 and TIN2 are negative regulators of telomere length, while tankyrase and
Rap1 act as positive regulators
Ye et al., J Biol Chem 2004
:
TIN2 binds TRF1 and TRF2 simultaneously and
stabilizes the
TRF2 complex on telomeres
Kendellen et al., Mol Cell Biol 2009
:
Mechanistically, expression of
POT1 ( DeltaOB )
reduced the association of
TRF2 with POT1, RAP1, and TIN2 ; however, of these proteins, only ectopic expression of POT1 suppressed the telomere elongation induced by POT1 ( DeltaOB )