Zhang et al., Biochem Pharmacol 2007
:
Tanshinone IIA potentiated tumor necrosis factor alpha (TNF-alpha) mediated nuclear accumulation of Nrf2 and expression of ARE related genes, while it reversed TNF-alpha induced down-regulation of intracellular glutathione ( GSH ), NADPH and glucose 6-phosphate dehydrogenase ( G6PDH ) levels
Spolarics et al., Life Sci 1997
:
These data indicate that the proinflammatory cytokine TNF alpha plays an important role in the regulation of cellular G6PD expression in hepatic immune competent cells