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ALK — CASP5

Text-mined interactions from Literome

Kim et al., J Biol Chem 2004 (Carcinoma, Hepatocellular...) : Short interfering RNA mediated inhibition of Smad3 markedly suppressed ALK7 induced caspase-3 activation
Xu et al., J Clin Endocrinol Metab 2004 (Ovarian Neoplasms) : Transient transfection of Nodal and ALK7-ca significantly decreased X-linked inhibitor of apoptosis protein ( Xiap ) expression, activated both caspase-3 and caspase-9, and increased apoptosis as determined by Hoechst nuclear staining and flow cytometry ... These findings demonstrate that Nodal induces apoptosis and inhibits proliferation via ALK7 and Smad2/3 and that the effect of Nodal-ALK7 on apoptosis may be mediated in part by the down-regulation of Xiap and activation of caspase-9 and caspase-3
Xu et al., Mol Cancer Res 2006 (Carcinoma...) : Silencing of Bax by small interfering RNA in IOSE397 cells significantly reduced ALK7-ca induced apoptosis as measured by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling assay but partially blocked ALK7-ca induced caspase-3 activation and did not affect the down-regulation of Xiap by ALK7-ca. Dominant negative Smad2, Smad3, and Smad4 blocked ALK7-ca regulated Xiap and Bax expression and caspase-3 activation