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SMAD3 — TOB2

Text-mined interactions from Literome

Yoshida et al., Cell 2000 : Negative regulation of BMP/Smad signaling by Tob in osteoblasts ... The results indicate that Tob negatively regulates osteoblast proliferation and differentiation by suppressing the activity of the receptor regulated Smad proteins
Tzachanis et al., Nat Immunol 2001 : Tob associated with Smad2 and Smad4 and enhanced Smad DNA binding ... The inhibitory effect of Tob on interleukin 2 (IL-2) transcription was not mediated by blockade of NFAT, AP-1 or NF-kappaB transactivation but by enhancement of Smad binding on the -105 negative regulatory element of the IL-2 promoter