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CTGF — PTH

Text-mined interactions from Literome

Guo et al., Nephrol Dial Transplant 2011 : Quantitative real-time RT-PCR analysis revealed that PTH at a concentration of 10 ( -12 ) -10 ( -10 ) ?M increased the mRNA levels of CTGF , which was similar to the trends of CTGF protein levels detected by immunoblotting assay ... Moreover, both PD98059 and PDTC inhibited the effect of PTH on the expression of CTGF, which strongly suggests that these pathways play important roles in the PTH induced CTGF upregulation in renal tubular cells ... Our results indicated for the first time that PTH may enhance the expression of CTGF in human kidney proximal tubular cells, suggesting that PTH may play an important role in the fibrotic and inflammatory process that is a hallmark for progression of chronic kidney disease
Guo et al., Chin Med J (Engl) 2010 (Fibrosis...) : PD98059 inhibited the PTH stimulated expression of CTGF, which strongly suggested that the MAPK signaling pathway plays an important role in the PTH induced CTGF upregulation in renal tubular cells ... A PKA activator as well as PKC activators induced MAPK phosphorylation, and both PKA and PKC inhibitors antagonized PTH induced MAPK phosphorylation and CTGF expression