◀ Back to F2RL2

F2RL2 — F2RL3

Pathways - manually collected, often from reviews:

• NCI Pathway Database PAR4-mediated thrombin signaling events: PAR4 (F2RL3) → Thrombin/PAR3 complex (F2-F2RL2) (modification, collaborate)
  Nakanishi-Matsui et al., Nature 2000, Faruqi et al., J Biol Chem 2000, Covic et al., Biochemistry 2000, Kataoka et al., Blood 2003, Xu et al., Proc Natl Acad Sci U S A 1998*, Kahn et al., Nature 1998*
  Evidence: mutant phenotype, assay
• NCI Pathway Database PAR4-mediated thrombin signaling events: Thrombin/PAR3 complex (F2-F2RL2) → PAR4 propeptide (F2RL3) (modification, activates) Nakanishi-Matsui et al., Nature 2000, Faruqi et al., J Biol Chem 2000, Covic et al., Biochemistry 2000, Kataoka et al., Blood 2003, Xu et al., Proc Natl Acad Sci U S A 1998*, Kahn et al., Nature 1998*
  Evidence: mutant phenotype, assay
• NCI Pathway Database PAR4-mediated thrombin signaling events: Thrombin/PAR3 complex (F2-F2RL2) → PAR4-active (F2RL3) (modification, activates) Nakanishi-Matsui et al., Nature 2000, Faruqi et al., J Biol Chem 2000, Covic et al., Biochemistry 2000, Kataoka et al., Blood 2003, Xu et al., Proc Natl Acad Sci U S A 1998*, Kahn et al., Nature 1998*
  Evidence: mutant phenotype, assay
• Reactome Reaction: F2RL2 → F2RL3 (reaction) Rubio et al., Genomics 1999, Coughlin et al., Journal of thrombosis and haemostasis : JTH 2005, Vu et al., Cell 1991, Dowal et al., J Biol Chem 2006, Amatruda et al., Proc Natl Acad Sci U S A 1991, Ferguson et al., J Biol Chem 1986, Offermanns et al., Proc Natl Acad Sci U S A 1994, Chen et al., Biochim Biophys Acta 1996, Ishihara et al., Nature 1997*, Xu et al., Proc Natl Acad Sci U S A 1998*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: F2RL2 — F2RL3 (in vivo) Nakanishi-Matsui et al., Nature 2000

Text-mined interactions from Literome

Cottrell et al., Essays Biochem 2002 (Inflammation) : Thrombin activates PAR1, PAR3 and PAR4, trypsin activates PAR2 and PAR4 , and mast cell tryptase activates PAR2 in this manner
Arachiche et al., PloS one 2013 : However, PAR4 is a relatively poor thrombin substrate and requires PAR3 as a cofactor at low thrombin concentrations ... In this study we show that PAR3 also regulates PAR4 signaling