Gene interactions and pathways from curated databases and text-mining

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APOE — IL6

Text-mined interactions from Literome

Patel et al., Neurosci Lett 2004 : In adult glia, IL-6 increased ApoE secretion, but slightly decreased ApoJ ... In contrast to adult glia, neonatal ApoJ secretion did not respond to IL-1 beta, IL-6, or TNFalpha, and ApoE secretion from neonatal glia was slightly increased by IL-6
Yamagata et al., Neurochem Int 2013 (Stroke) : Dietary ß-carotene regulates interleukin-1ß induced expression of apolipoprotein E in astrocytes isolated from stroke-prone spontaneously hypertensive rats
Wei et al., Neurobiol Dis 2013 : We observed that the absence of apoE resulted in the increased proportion of Th1 and Th17 cells in the spleens and brains, as well as up-regulated expressions of proinflammatory cytokines ( IL-17, IFN-?, TNF-a, IL-12, IL-1ß and IL-6 ) and transcription factors ( ROR?t and T-bet ) in the CNS
Fuhrman et al., Atherosclerosis 1994 : Macrophage lipid peroxidation increases cell mediated oxidation of LDL, enhances the release of interleukin 1 and inhibits the release of apolipoprotein E from the macrophages