Mathews et al., Arterioscler Thromb Vasc Biol 2008
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PARP-1 inhibition increased Akt, BAD, and VEGFR2 phosphorylation in HUVECs and in PJ34 treated rabbit aortas
Lakshmikanthan et al., Blood 2011
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Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin avß3 ... Using ECs obtained from Rap1-deficient mice we demonstrate that Rap1b promotes VEGF-VEGFR2 kinase activation and regulates integrin activation ... Importantly, the Rap1b dependent VEGF-VEGFR2 activation is in part mediated via integrin a ( v ) ß ( 3 )