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KLF4 — NOTCH1
Text-mined interactions from Literome
Ghaleb et al., Mol Cancer Res 2008
(Adenoma...) :
Conversely, overexpression of
Notch in HT29 cells
reduced KLF4 levels, suppressed KLF4 promoter activity, and increased proliferation rate ... Inhibition of
Notch signaling
increases KLF4 expression and goblet cell differentiation and reduces proliferation and tumor formation
Zheng et al., Am J Physiol Gastrointest Liver Physiol 2009
:
The aim of this study was to examine whether
Notch represses
KLF4 expression to regulate goblet cell differentiation ... In a colon cancer cell line ( HCT116 cells ),
KLF4 promoter activity was
inhibited by a constitutively active form of
Notch1 ( ICN1 ) by transient cotransfection assays ... Our findings thus reveal a possible mechanism by which
KLF4 is
inhibited by
Notch , which controls goblet cell differentiation in mouse gastrointestinal tract
Liu et al., Cancer Biol Ther 2009
(Breast Neoplasms...) :
Chromatin immunoprecipitation assay shows that
KLF4 binds to the proximal Notch1 promoter in human mammary epithelial cells, and siRNA mediated suppression of KLF4 in human mammary cancer cells
results in reduced expression of
Notch1