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PTPRC — TNF

Text-mined interactions from Literome

Blank et al., J Immunol 2001 : Costimulation with OKT-3 and IL-2 optimally induced secretion of IFN-gamma, TNF-alpha , and IL-5, which was not decreased by CD45 signals
Spertini et al., Immunology 2004 : CD45 engagement by monoclonal antibodies on human activated T cells triggers tumour necrosis factor-alpha (TNF-alpha) gene transcription in an epitope-specific manner
Estoppey et al., Eur J Immunol 1996 : Epitope-specific engagement of the protein tyrosine phosphatase CD45 induces tumor necrosis factor-alpha gene expression via transcriptional mechanisms ... We here demonstrate that engagement of CD45 by monoclonal antibodies ( mAb ) on activated T cells induces tumor necrosis factor (TNF)-alpha as well as TNF-beta, interleukin (IL)-2 and IL-3 gene expression ... Nuclear run-on transcription assays demonstrated that CD45 cross linking caused transcriptional activation of the TNF-alpha gene ... CD45 ligation resulted in TNF-alpha secretion
Brown et al., Diabetologia 1998 (Diabetes Mellitus, Type 1...) : Lymphoid hyperplasia, CD45RBhigh to CD45RBlow T-cell imbalance, and suppression of Type I diabetes mellitus result from TNF blockade in NOD -- > NOD-scid adoptive T cell transfer