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FST — MAPK1
Text-mined interactions from Literome
Winters et al., Mol Cell Endocrinol 2007
(Second Messenger Systems) :
The MEK inhibitor PD98059 blocked activation by GnRH or forskolin implying that
MAPK contributes to cAMP/PKA mediated activation of
follistatin
Galeotti et al., Int J Neuropsychopharmacol 2012
(MAP Kinase Signaling System) :
In the frontal cortex, the
FST and TST produced a PKC dependent
increase of ERK2 and
p38MAPK phosphorylation, a PKC independent activation of JNK and cAMP response element binding protein ( CREB ) whereas any involvement of ERK1 was detected
Galeotti et al., Neuropharmacology 2012
(Disease Models, Animal) :
A differential pattern of activation was observed in the frontal cortex where
FST selectively
increased PKC?,
ERK2 , JNK-l and JNK-s
Arai et al., Endocrinology 2011
(MAP Kinase Signaling System) :
A p38 MAPK inhibitor, SB202190, a
MAPK/ERK kinase inhibitor, U0126, and an nuclear factor ?B pathway inhibitor, SC-514, significantly
suppressed the IL-1ß stimulated INHBA and
FST mRNA expression