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HMGA2 — SLC22A3
Text-mined interactions from Literome
Thuault et al., J Cell Biol 2006
:
Endogenous
HMGA2 mediates EMT by TGF-beta, whereas ectopic HMGA2
causes irreversible
EMT characterized by severe E-cadherin suppression
Thuault et al., J Biol Chem 2008
(Neoplasm Metastasis...) :
In the present study we investigated the molecular mechanisms by which
HMGA2 induces
EMT
Zha et al., Mol Cell Biochem 2012
(Neoplasm Invasiveness...) :
To our knowledge, this is the first report on the genome-wide analysis of HMGA2 downstream direct targets, and these findings will be valuable in understanding the
roles of
HMGA2 in
EMT
Morishita et al., Cancer Res 2013
:
Ectopic expression of
HMGA2 in epithelial cells
induces epithelial-mesenchymal transition (EMT) , which has been implicated in the acquisition of metastatic characters in tumor cells ... Together our results argued that
HMGA2 plays a critical role in
EMT by activating the TGFß signaling pathway, thereby inducing invasion and metastasis of human epithelial cancers