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IL1B — TRAF6
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
TRAF6
→
IL1B
(increases)
Zirlik et al., Arterioscler Thromb Vasc Biol 2007*
Evidence: Stimulation with IL-1 or TNF- induced expression of TRAF-1, -3, and -6 in ECs and SMCs, whereas neither stimulus affected the constitutive expression of TRAF-2 or -5 (Figure 1).
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NCI Pathway Database IL1-mediated signaling events:
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP)
→
TRAF6 (TRAF6)
(modification, collaborate)
Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
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NCI Pathway Database IL1-mediated signaling events:
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP)
→
IRAK/TRAF6 complex (IRAK1-TRAF6)
(modification, collaborate)
Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
TRAF6 (TRAF6)
→
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP)
(modification, collaborate)
Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
IRAK/TRAF6 complex (IRAK1-TRAF6)
→
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP)
(modification, collaborate)
Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
TRAF6 (TRAF6)
→
IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 complex (IL1B-IL1R1-IL1RAP-TICAM2-IRAK4)
(modification, collaborate)
Bin et al., J Biol Chem 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 complex (IL1B-IL1R1-IL1RAP-TICAM2-IRAK4)
→
IRAK/TRAF6 complex (IRAK1-TRAF6)
(modification, activates)
Bin et al., J Biol Chem 2003
Evidence: mutant phenotype, physical interaction
-
Reactome Reaction:
IL1B
→
TRAF6
(indirect_complex)
Cao et al., Nature 1996
-
Reactome Reaction:
IL1B
→
TRAF6
(reaction)
Gottipati et al., Cell Signal 2008, Cao et al., Nature 1996
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wu et al., Cell Signal 2009
:
Furthermore, co-transfection study shows that HSP27 S78/82A, two phosphorylated serine site deficient mutants, but not wild-type HSP27 ( HSP27 WT ) and HSP27 S15A mutant increases
TRAF6 ubiquitination and thereby
mediates IL-1beta triggered IKK phosphorylation
Ahmad et al., J Immunol 2009
:
The
role and relative contribution of MyD88, IRAK1, and
TRAF6 adaptor proteins in
IL-1beta regulation of aggrecanase-1 ( ADAMTS-4 ) is unknown