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CD79A — IL6

Text-mined interactions from Literome

Goodrich et al., Cytokine 1998 : Depletion of the IEC-6 supernatant using cytokine specific antibodies revealed that both interleukin 6 (IL-6) and transforming growth factor beta ( TGF-beta ) were responsible for the enhanced IgA secretion while TGF-beta suppressed IgM secretion
Goodrich et al., Immunol Invest 1999 : Recently, we determined that IEC derived IL-6 and TGF-beta could enhance IgA secretion and suppress IgM secretion by isolated mucosal B cells ... Depletion of the IEC-SN with specific anti-cytokine antibodies suggested that IEC derived TGF-beta and IL-6 were both responsible for the enhancing effect along with IL-2 on IgA secretion, whereas IEC derived TGF-beta alone limited or suppressed IgM secretion
Wu et al., Ann Surg 1999 : To examine the levels of a Th1 IgA inhibiting cytokine ( interferon gamma ) and the Th2 IgA stimulating cytokines ( interleukin [IL]-4, IL-5, IL-6 , and IL-10 ) within the intestine of animals manipulated with enteral or parenteral nutrition, and to correlate these cytokine alterations with intestinal IgA levels
Pritts et al., Am J Surg 2002 (Endotoxemia...) : Mucosal IL-6 may regulate enterocyte acute phase protein synthesis and intestinal IgA production
Deviere et al., Gastroenterology 1992 (Liver Cirrhosis, Alcoholic) : PBMCs and purified monocytes isolated from healthy control subjects and patients with ALC contain elevated IL-6 messenger RNA levels and produce IL-6 in response to stimulation with soluble polymeric IgA (p-IgA) or attached monomeric IgA ( m-IgA ) but not with soluble m-IgA
Fujihashi et al., Res Immunol 1992 (Inflammation) : When the effect of IL6 on IgA subclass antibody synthesis was examined, the numbers of both IgA1- and IgA2 producing cells were increased upon incubation of GALT B cells with IL6 ; however, 60-70 % of IgA secreting cells were IgA2 subclass
Sato et al., J Immunol 2003 : CD11b+ Peyer 's patch dendritic cells secrete IL-6 and induce IgA secretion from naive B cells ... Finally, we demonstrated that only PP CD11b ( + ) DC subset secreted higher levels of IL-6 compared with other DC subsets in the PP and all SP DC populations, and that PP CD11b ( + ) DC induced naive B cells to produce higher levels of IgA compared with SP CD11b ( + ) DC
Kono et al., Am J Physiol Gastrointest Liver Physiol 2004 : The mRNA expression of IL-6 was assessed by real-time RT-PCR, because IL-6 regulates secretory IgA in the intestine
Ray et al., Mol Immunol 2004 : The porin mediated induction of IgA was augmented by interleukin-6 on B-1a and B-1b cells, by 2.4- and 2.6-fold, respectively
Ray et al., Immunology 2005 : The porin mediated inductions of IgG2a and IgA were augmented by interleukin-6 on B-2 cells, by 2.7- and 1.6-fold, respectively
Giri et al., FEMS Immunol Med Microbiol 2005 (Disease Models, Animal...) : Vaccination via intranasal and subcutaneous routes triggered immune activation in the spleen and cervical lymph node, while the former route of vaccination lead to higher antigen-specific lymphocyte proliferation, interferon-gamma, interleukin-12 and interleukin-4 responses in cervical lymph node and induction of antigen-specific IgA responses at mucosal level of the respiratory tract
Leung et al., Nephrol Dial Transplant 2008 : Our results suggest that polymeric anionic IgA1 could activate HMC and increase the synthesis of TNF-alpha and IL-6
Reterink et al., Mediators Inflamm 1996 : Dimeric and polymeric IgA , but not monomeric IgA, enhance the production of IL-6 by human renal mesangial cells ... In this report we show that human mesangial cells ( MC ) in vitro bind IgA and that binding of IgA enhances the production of IL-6 by MC
Shi et al., J Nutr Biochem 2009 : Consumption of the trichothecene mycotoxin deoxynivalenol ( DON ) induces interleukin-6 (IL-6) dependent IgA nephropathy (IgAN) in mice
Beagley et al., Cytokine 1991 : Increased IgA secretion was totally abolished by actinomycin D, an inhibitor of RNA transcription, showing that continued production of alpha mRNA is essential for IL-6 induced IgA secretion
Li et al., J Immunol 1991 : However, addition of anti-mouse IL-6 antibody did not prevent PMA enhanced IgA secretion, suggesting that IL-6 was not responsible for IgA induction by PMA
Tam et al., Kidney Int 2009 (Glomerulonephritis, IGA...) : Further, when we tested the effects of the macromolecular IgA1 on human mesangial cells in culture, we found that the macromolecular IgA1 taken from familial clusters had enhanced binding to mesangial cells and caused increased expression of interleukin-6 , tumor necrosis factor-alpha, and monocyte chemotactic peptide-1
McGhee et al., Immunol Res 1991 : Role of interleukin-6 in human and mouse mucosal IgA plasma cell responses
Saito et al., J Reprod Immunol 1991 : Detection of IL-6 in human milk and its involvement in IgA production
Pockley et al., Immunology 1991 : This study investigated the effect of IL-5 and IL-6 on antigen-specific tear IgA antibody responses in vivo
Bertolini et al., Cell Immunol 1990 : Recombinant human IL-6 enhances immunoglobulin ( Ig ) M and G secretion by B-cells activated by Staphylococcal A Cowan strain ( SAC ) and enhances IgM, IgG, and IgA secretion by B-cells activated by pokeweed mitogen
Maiolini et al., BMC veterinary research 2013 (Arteritis...) : To investigate if transforming growth factor beta 1 ( TGF-ß1 ), interleukin-6 (IL-6) and vascular endothelial growth factor ( VEGF ) are involved in the production of excessive immunoglobulin A (IgA) , the induction of acute phase proteins and in the development of a systemic necrotizing vasculitis, characteristic of SRMA, these three signalling proteins were evaluated ... To investigate if transforming growth factor beta 1 ( TGF-ß1 ), interleukin-6 (IL-6) and vascular endothelial growth factor ( VEGF ) are involved in the production of excessive immunoglobulin A (IgA) , the induction of acute phase proteins and in the development of a systemic necrotizing vasculitis, characteristic of SRMA, these three signalling proteins were evaluated
Beagley et al., Immunol Invest 1989 : PP T helper (Th) cells support IgA responses, and interleukins 5 (IL-5) and IL-6 can augment secretion of this isotype
Beagley et al., J Exp Med 1989 : Human and murine interleukin 6 induce high rate IgA secretion in IgA committed B cells
Kunimoto et al., J Immunol 1989 : In contrast, IgA production was only modestly increased above baseline by rIL-1, rIL-5, or IL-6 alone or by rIL-1 and IL-6 in combination, but was greatly increased by rIL-5 and IL-6 in combination
van den Dobbelsteen et al., Kidney Int 1994 : Binding of dimeric and polymeric IgA to rat renal mesangial cells enhances the release of interleukin 6 ... Dimeric IgA and pIgA both induced a dose dependent increase of IL-6 production by MC. ( ABSTRACT TRUNCATED AT 250 WORDS )
Wolf et al., Blood 1994 : Regulation of TNF-alpha and IL-6 release by IgA may be among the antiinflammatory mechanisms preventing an uncontrolled release of potentially noxious levels of inflammatory cytokines during acute and/or chronic inflammation
Oen et al., J Rheumatol 1993 : Our results suggest that IL-6 may promote the production of IgG and IgA RF and IgG antinative type II collagen antibodies
Kimata et al., Biotechnol Ther 1993 : Of various cytokines tested, including IFN-alpha, IFN-gamma, IL-1 beta, IL-2, IL-3, IL-4, IL-5, and IL-6 , IL-6 alone augmented IgG2 induced enhancement of IgA production and proliferation
Bromander et al., J Immunol 1996 (Helicobacter Infections) : Using IL-6-deficient (IL-6 -/-) or wild-type mice, we investigated whether IL-6 is involved in the intestinal adjuvant activity of cholera toxin ( CT ) and to what extent IL-6 is required for mucosal IgA responses against soluble protein Ags or live Helicobacter felis infection ... We conclude that, although IL-6 has been ascribed a crucial role in terminal differentiation of IgA B cells in vitro, we found no evidence to support the notion that IL-6 is critically required for IgA B cell development or specific mucosal IgA responses in vivo
Emilie et al., Methods 1997 (Acquired Immunodeficiency Syndrome...) : However, IL-6 contributes to increased production of IgG and IgA in vivo
Yan et al., Toxicology 1997 : Potential role for IL-5 and IL-6 in enhanced IgA secretion by Peyer 's patch cells isolated from mice acutely exposed to vomitoxin
Boyaka et al., J Immunol 1999 (Tetanus) : In summary, both intranasal IL-6 and IL-12 induced serum Abs that protected mice from systemic challenge with TT, whereas only IL-12 induced mucosal S-IgA Ab responses