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CTTN — EPHB2
Text-mined interactions from Literome
Martinez-Quiles et al., Mol Cell Biol 2004
:
Erk phosphorylation and a mimicking S405,418D double mutation
enhanced cortactin binding and activation of N-WASP
Ayala et al., J Cell Sci 2008
(Melanoma...) :
In addition, through a combination of RNA interference and a wide array of cortactin phosphorylation mutants, we were able to show that three convergent regulatory inputs based on the
regulation of
cortactin phosphorylation by Src-family kinases,
Erk1/Erk2 and PAK are necessary for invadopodia formation and extracellular matrix degradation
Seese et al., J Neurosci 2012
(MAP Kinase Signaling System) :
We propose that, in the KOs, excessive basal phosphorylation of
ERK1/2 disrupts its interactions with
cortactin , thereby blocking the latter protein 's use of actomyosin transport systems